Review Article

Application of Nanoparticles on Diagnosis and Therapy in Gliomas

Table 2

Nanoparticles proposed as candidates for the treatment of glioblastoma multiforme.

NanoparticleStructureFunctionFigure

LiposomesBilayered vesicles conjugated with some proteins or drugs (i.e., anfotericine) for recognition and/or lists of cancer cellsDue to their amphiphilic structure, it is feasible to manipulate surface modification and/or conjugate them with biomolecules to increase the circulating half-life and deliver antineoplastic drugs in tumoral areas351031.table.002a

Solid lipid nanoparticles
Submicron colloidal carriers that could be loaded with others types of chemotherapeutics or specific antibodiesCurrently, these particles are under research, but they could deliver chemotherapeutic agents into neoplastic cells due to their biocompatible and fusionable membranes351031.table.002b

Drugs or toxin conjugated nanoparticlesThe satisfactory size of nanoparticles allows to encapsulate anti-neoplastic drugs, toxins, or specific antibodies directed to membrane-bound antigens in cancer cellsThese nanoconjugates deliver their drug load to increase local levels of apoptotic molecules near tumors or to accumulate in focal areas to exert their cytotoxic effect351031.table.002c

NanocrystalsCrystalline aggregates of hydrophobic molecules coated with a thin hydrophilic layerDepending of the size of crystals several protein-metal conjugates can originate nanorods or nanowires which could enhance thermosensitivity of cancer cells351031.table.002d

NanotubesSingle or multilayered sheets of self-assembling organic or inorganic atoms Due to their large inner volume and great external surface could be drug-loaded and may induce cellular death351031.table.002e

DendrimersMonomeric or oligomeric multibranched structures whose exterior-end groups can be conjugated to drugs, antibodies, or metal atomsThese symmetrical particles may encapsulate drugs, targeting moieties, antibodies, and functional groups to carry and deliver them inside tumor351031.table.002f