Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth

Table 1

(a) Relative organs weight of male rats orally treated daily with 50% methanolic extract of Orthosiphon stamineus for 28 days. (b) Relative organs weight of female rats orally treated daily with 50% methanolic extract of Orthosiphon stamineus for 28 days (cont’).

(a)

% organ weight/bodyweight	Treatment for 28 days
	Control	50% methanolic extract of Orthosiphon stamineus
		1250 mg/kg	2500 mg/kg	5000 mg/kg
Male
Brain	0.42±0.02	0.39±0.01	0.43±0.02	0.42±0.02
Heart	1.54±0.03	1.44±0.13	1.43±0.08	1.37±0.06
Liver	2.34±0.10	2.42±0.16	2.48±0.15	2.46±0.14
Thymus	0.14±0.01	0.16±0.01	0.15±0.01	0.15±0.01
Spleen	0.27±0.02	0.27±0.01	0.25±0.01	0.27±0.02
Kidney (right)	0.35±0.01	0.37±0.02	0.33±0.01	0.35±0.01
Kidney (left)	0.32±0.01	0.33±0.01	0.32±0.01	0.33±0.01
Adrenal gland	0.01±0.00	0.02±0.00	0.01±0.00	0.01±0.00
Lungs	0.67±0.05	0.71±0.06	0.63±0.02	0.63±0.03
Testis (right)	0.56±0.02	0.54±0.01	0.55±0.01	0.55±0.02
Testis (left)	0.54±0.03	0.55±0.01	0.54±0.02	0.56±0.01
Stomach	2.74±0.31	2.63±0.06	2.93±0.08	2.56±0.11
Stomach (empty)	0.57±0.01	0.59±0.01	0.51±0.02	0.54±0.02
Gut	6.64±0.21	6.38±0.14	6.45±0.14	6.32±0.30
Gut (empty)	3.27±0.03	3.44±0.11	3.17±0.04	3.24±0.13

Data are expressed as mean ± SEM.

(b)

% organ weight/bodyweight	Treatment for 28 days
	Control	50% methanolic extract of Orthosiphon stamineus
		1250 mg/kg	2500 mg/kg	5000 mg/kg
Female
Brain	0.40±0.00	0.39±0.00	0.40±0.01	0.38±0.01
Heart	1.70±0.03	1.65±0.02	1.68±0.02	1.60±0.04
Liver	2.61±0.08	2.69±0.09	2.81±0.04	2.66±0.06
Thymus	0.11±0.01	0.09±0.01	0.09±0.00	0.10±0.01
Spleen	0.22±0.01	0.25±0.02	0.23±0.02	0.24±0.01
Kidney (right)	0.28±0.01	0.27±0.01	0.28±0.01	0.26±0.01
Kidney (left)	0.27±0.00	0.27±0.01	0.28±0.00	0.26±0.01
Adrenal gland	0.02±0.00	0.02±0.00	0.02±0.00	0.02±0.00
Lungs	0.66±0.01	0.63±0.02	0.65±0.02	0.67±0.03
Ovaries	0.13±0.01	0.09±0.01	0.10±0.01	0.11±0.01
Uterus	0.21±0.00	0.16±0.01	0.19±0.02	0.15±0.01
Stomach	2.74±0.18	2.71±0.14	2.71±0.06	2.69±0.09
Stomach (empty)	0.58±0.01	0.53±0.01	0.51±0.01	0.50±0.01
Gut	7.29±0.25	6.82±0.21	6.80±0.11	6.94±0.30
Gut (empty)	4.06±0.08	3.83±0.11	3.63±0.13	3.82±0.15

Data are expressed as mean ± SEM.