Poly-S-Nitrosated Albumin as a Safe and Effective Multifunctional Antitumor Agent: Characterization, Biochemistry and Possible Future Therapeutic Applications

Figure 4

Synergistic effects of doxorubicin (dx) and Poly-SNO-HSA on the viability of K562 parental cells and doxorubicin-resistant K562 (K562/dx) cells. K562 cells (open circles) and K562/dx cells (closed circles) were treated for 24 h with various concentrations of dx (a) or Poly-SNO-HSA (b). In panel (c), K562 cells and K562/dx cells were treated with dx (5 μM) for 24 h following incubation with various concentrations of Poly-SNO-HSA for 2  h. Data are expressed as means ± SD (𝑛=3). *𝑃<0.01, compared with K562 cells [29, 30].

(a)

(b)

(c)