Poly-S-Nitrosated Albumin as a Safe and Effective Multifunctional Antitumor Agent: Characterization, Biochemistry and Possible Future Therapeutic Applications

Figure 5

Effects of dx and Poly-SNO-HSA on tumor growth in vivo. K562 tumor-bearing mice (a) and K562/dx tumor-bearing mice (b) were given injections of saline (5 mL/kg), dx (4 mg/kg), Poly-SNO-HSA (10 μmol/5 mL/kg), or dx combined with Poly-SNO-HSA biweekly as noted (↑). Results are means ± SD; 𝑛 = 3-4 animals per experimental group. (c) Results are shown for one representative experiment of K562/dx tumor-bearing mice. *𝑃<0.05, **𝑃<0.01, compared with control (saline) [33].

(a)

(b)

(c)