Table 2: Study outcomes evaluated as change from the baseline.

BaselineChange from baseline at day 8Change from baseline at day 14
VariablesActive group
( )
Control group
( )
Active group
( )
Control group
( )
Active group
( )
Control group
( )

FEV1, litres1.9 ± 0.51.6 ± 0.60.0 ± 0.3 (0)0.0 ± 0.2 (0)0.1 ± 0.3 (5)*0.1 ± 0.2 (6)*
 % predicted69.8 ± 18.464.7 ± 15.03.6 ± 10.2 (5)2.6 ± 8.5 (4)6.5 ± 10.1 (9)*6.0 ± 10.6 (9)*
FVC, litres2.4 ± 0.72.1 ± 0.90.1 ± 0.5 (4)0.0 ± 0.3 (0)0.2 ± 0.6 (8)*0.2 ± 0.4 (10)*
 % predicted69.7 ± 15.066.3 ± 15.34.9 ± 11.2 (7)*4.5 ± 11.8 (7)8.8 ± 13.0 (13)**8.3 ± 12.6 (13)*
VC, litres2.5 ± 0.52.3 ± 0.70.1 ± 0.3 (4)*0.0 ± 0.4 (0)0.2 ± 0.2 (8)**0.3 ± 0.4 (13)*
 % predicted68.3 ± 11.762.6 ± 13.63.7 ± 7.1 (5)*3.6 ± 11.4 (6)4.3 ± 5.1 (6)**6.6 ± 12.3 (11)*
IC, litres2.8 ± 3.81.8 ± 0.7−0.6 ± 3.8 (−21)0.1 ± 0.6 (6)−0.5 ± 3.8 (−18)0.2 ± 0.7 (11)
 % predicted74.4 ± 16.070.1 ± 14.73.4 ± 12.3 (5)3.1 ± 13.2 (4)5.1 ± 11.7 (7)*6.5 ± 17.0 (9)
TLC, litres5.4 ± 1.04.9 ± 1.20.2 ± 0.6 (4)0.2 ± 0.9 (4)0.1 ± 0.8 (2)0.4 ± 1.0 (8)
 % predicted86.6 ± 13.184.6 ± 15.53.2 ± 10.3 (4)3.5 ± 10.7 (4)6.9 ± 13.5 (8)*4.1 ± 15.9 (5)
RV, litres2.7 ± 0.92.2 ± 1.1−0.1 ± 1.0 (−4)0.1 ± 0.8 (5)−0.0 ± 0.9 (0)0.3 ± 1.0 (14)
 % predicted113.4 ± 37.297.5 ± 44.0−7.1 ± 39.5 (−6)6.3 ± 37.0 (6)1.1 ± 29.8 (1)15.7 ± 35.5 (16)*
MIP, mmHg59.9 ± 28.953.4 ± 21.38.1 ± 13.9 (14)*7.5 ± 15.3 (14)*13.3 ± 23.1 (22)*13.4 ± 18.6 (25)*
 % predicted60.5 ± 28.456.0 ± 20.59.5 ± 17.6 (16)*5.6 ± 16.3 (10)13.5 ± 22.5 (22)*13.0 ± 16.5 (23)*
MEP, mmHg83.5 ± 23.776.8 ± 30.815.1 ± 16.1 (18)**8.7 ± 17.5 (11)*34.2 ± 24.9 (41)**10.8 ± 18.3 (14)*
 % predicted46.0 ± 14.643.5 ± 16.57.6 ± 10.7 (17)**3.3 ± 15.5 (8)26.1 ± 32.4 (57)**7.4 ± 19.9 (17)
PaO2/FiO2, %343.3 ± 47.8337.6 ± 51.522.9 ± 34.6 (7)*32.4 ± 52.6 (10)*
PaCO2, mmHg34.2 ± 4.835.5 ± 5.20.8 ± 3.8 (2)−0.7 ± 4.4 (−2)
Distance walked at 6 MWT, meters308.9 ± 86.7295.3 ± 108.4125.6 ± 76.1 (41)**108.0 ± 74.7 (37)**
MRC, score2.1 ± 0.52.0 ± 0.5−1.0 ± 0.8 (−48)**−0.8 ± 0.3 (−40)**
SF36FI, score32.7 ± 6.633.5 ± 8.13.2 ± 6.4 (10)*4.5 ± 8.9 (13)*
SF36ME, score41.0 ± 11.041.5 ± 10.73.9 ± 5.8 (10)*3.2 ± 10.5 (8)

Variables described as mean ± SD. In parenthesis percentage of change from baseline.
No significant differences between active and control groups are reported in all baseline variables considered.
FEV1: forced expiratory volume in the first second; FVC: forced vital capacity; VC: vital capacity; IC: inspiratory capacity; TLC: total lung capacity; RV: residual volume; MIP: maximal inspiratory pressure; MEP: maximal expiratory pressure; PaO2/FiO2: arterial oxygen pressure on inspiratory oxygen fraction, ratio; PaCO2: arterial carbon dioxide pressure; 6 MWT: 6 min walking test; MRC: medical research council; SF36 PC and MC: short form 36 health survey questionnaire, physical and mental component, respectively.
* ; ** .