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BioMed Research International
Volume 2013 (2013), Article ID 354582, 13 pages
http://dx.doi.org/10.1155/2013/354582
Research Article

Comparative Gene Expression Profiling in Human Cumulus Cells according to Ovarian Gonadotropin Treatments

1Université Montpellier 1, UFR de Médecine, Montpellier, France
2CHU Montpellier, Institute for Research in Biotherapy, Hôpital Saint-Eloi, INSERM U1040, 34295 Montpellier, France
3ART-PGD Department, CHU Montpellier, Hôpital Arnaud de Villeneuve, 34295 Montpellier, France

Received 7 June 2013; Accepted 8 August 2013

Academic Editor: Shivani Soni

Copyright © 2013 Said Assou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material available online includes: (i) Baseline clinical characteristics, end-of-stimulation data and number of oocytes retrieved from each patient following controlled ovarian stimulation with HP-hMG or rFSH. (ii) Primer pairs used for validation of the array data by qRT-PCR. (iii) List of the 9,805 common genes expressed in both HP-hMG and rFSH CC samples. (iv) Validation by qRT-PCR of some of the genes that were differentially expressed in HP-hMG and rFSH CC samples. (v) Top-ranked networks evidenced in common HP-hMG/rFSH signature by Ingenuity Pathway software. (vi) Detailed list of the genes presented in the network. (vii) The major signaling pathways that occur in CCs following the gonadotropin (HP-hMG and rFSH) stimulation.

  1. Supplementary Material