About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 358015, 9 pages
http://dx.doi.org/10.1155/2013/358015
Research Article

Growth Arrest on Inhibition of Nonsense-Mediated Decay Is Mediated by Noncoding RNA GAS5

Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Huxley Building, Keele ST5 5BG, UK

Received 5 April 2013; Accepted 19 September 2013

Academic Editor: Xudong Huang

Copyright © 2013 Mirna Mourtada-Maarabouni and Gwyn T. Williams. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. T. Williams, J. P. Hughes, V. Stoneman et al., “Isolation of genes controlling apoptosis through their effects on cell survival,” Gene Therapy and Molecular Biology, vol. 10, no. 2, pp. 255–261, 2006. View at Scopus
  2. C. H. Rickert, B. Dockhorn-Dworniczak, R. Simon, and W. Paulus, “Chromosomal imbalances in primary lymphomas of the central nervous system,” American Journal of Pathology, vol. 155, no. 5, pp. 1445–1451, 1999. View at Scopus
  3. B. J. Dave, M. Nelson, D. L. Pickering et al., “Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization,” Cancer Genetics and Cytogenetics, vol. 132, no. 2, pp. 125–132, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. X. Mao, D. Lillington, J. J. Scarisbrick et al., “Molecular cytogenetic analysis of cutaneous T-cell lymphomas: identification of common genetic alterations in Sézary syndrome and mycosis fungoides,” British Journal of Dermatology, vol. 147, no. 3, pp. 464–475, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. B. P. Tsao, “Update on human systemic lupus erythematosus genetics,” Current Opinion in Rheumatology, vol. 16, no. 5, pp. 513–521, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. J. B. Harley, M. E. Alarcón-Riquelme, L. A. Criswell et al., “Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci,” Nature Genetics, vol. 40, no. 2, pp. 204–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Suarez-Gestal, M. Calaza, E. Endreffy et al., “Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study,” Arthritis Research & Therapy, vol. 11, no. 3, article R69, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. K. Haywood, S. J. Rose, S. Horswell et al., “Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes,” Genes and Immunity, vol. 7, no. 3, pp. 250–263, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Schneider, R. M. King, and L. Philipson, “Genes specifically expressed at growth arrest of mammalian cells,” Cell, vol. 54, no. 6, pp. 787–793, 1988. View at Scopus
  10. A. J. Muller, S. Chatterjee, A. Teresky, and A. J. Levine, “The Gas5 gene is disrupted by a frameshift mutation within its longest open reading frame in several inbred mouse strains and maps to murine chromosome 1,” Mammalian Genome, vol. 9, no. 9, pp. 773–774, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. G. T. Williams and F. Farzaneh, “Are snoRNAs and snoRNA host genes new players in cancer?” Nature Reviews Cancer, vol. 12, no. 2, pp. 84–88, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Lelièvre, N. Cervera, P. Finetti et al., “Oncogenic kinases of myeloproliferative disorders induce both protein synthesis and G1 activators,” Leukemia, vol. 20, no. 10, pp. 1885–1888, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Tsuji, H. Ishii-Ohba, H. Ukai, T. Katsube, and T. Ogiu, “Radiation-induced deletions in the 5′ end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas,” Carcinogenesis, vol. 24, no. 7, pp. 1257–1268, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Mourtada-Maarabouni, V. L. Hedge, L. Kirkham, F. Farzaneh, and G. T. Williams, “Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5),” Journal of Cell Science, vol. 121, no. 7, pp. 939–946, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Mourtada-Maarabouni, M. R. Pickard, V. L. Hedge, F. Farzaneh, and G. T. Williams, “GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer,” Oncogene, vol. 28, no. 2, pp. 195–208, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Mourtada-Maarabouni, A. M. Hasan, F. Farzaneh, and G. T. Williams, “Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5),” Molecular Pharmacology, vol. 78, no. 1, pp. 19–28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Meyuhas and A. Dreazen, “Ribosomal protein S6 kinase: from TOP mRNAs to cell size,” Progress in Molecular Biology and Translational Science, vol. 90, pp. 109–153, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. O. Meyuhas, “Synthesis of the translational apparatus is regulated at the translational level,” European Journal of Biochemistry, vol. 267, no. 21, pp. 6321–6330, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. C. M. Smith and J. A. Steitz, “Classification of Gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes,” Molecular and Cellular Biology, vol. 18, no. 12, pp. 6897–6909, 1998. View at Scopus
  20. K. T. Tycowski, M.-D. Shu, and J. A. Steitz, “A mammalian gene with introns instead of exons generating stable RNA products,” Nature, vol. 379, no. 6564, pp. 464–466, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. Y.-F. Chang, J. S. Imam, and M. F. Wilkinson, “The nonsense-mediated decay RNA surveillance pathway,” Annual Review of Biochemistry, vol. 76, pp. 51–74, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. F. He, X. Li, P. Spatrick, R. Casillo, S. Dong, and A. Jacobson, “Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5′ to 3′ mRNA decay pathways in yeast,” Molecular Cell, vol. 12, no. 6, pp. 1439–1452, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Brogna and J. Wen, “Nonsense-mediated mRNA decay (NMD) mechanisms,” Nature Structural and Molecular Biology, vol. 16, no. 2, pp. 107–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Nicholson and O. Mühlemann, “Cutting the nonsense: the degradation of PTC-containing mRNAs,” Biochemical Society Transactions, vol. 38, no. 6, pp. 1615–1620, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Hilleren and R. Parker, “Mechanisms of mRNA surveillance in eukaryotes,” Annual Review of Genetics, vol. 33, pp. 229–260, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Avery, M. Vicente-Crespo, D. Francis, O. Nashchekina, C. R. Alonso, and I. M. Palacios, “Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner,” RNA, vol. 17, no. 4, pp. 624–638, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. J. T. Mendell, C. M. J. Ap Rhys, and H. C. Dietz, “Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts,” Science, vol. 298, no. 5592, pp. 419–422, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. C. M. Azzalin and J. Lingner, “The double life of UPF1 in RNA and DNA stability pathways,” Cell Cycle, vol. 5, no. 14, pp. 1496–1498, 2006. View at Scopus
  29. L. S. Correa-Cerro, C. A. Wassif, J. S. Waye et al., “DHCR7 nonsense mutations and characterisation of mRNA nonsense mediated decay in Smith-Lemli-Opitz syndrome,” Journal of Medical Genetics, vol. 42, no. 4, pp. 350–357, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Salvatori, V. Cantale, G. Breveglieri et al., “Development of K562 cell clones expressing β-globin mRNA carrying the β039 thalassaemia mutation for the screening of correctors of stop-codon mutations,” Biotechnology and Applied Biochemistry, vol. 54, no. 1, pp. 41–52, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Ideue, Y. T. F. Sasaki, M. Hagiwara, and T. Hirose, “Introns play an essential role in splicing-dependent formation of the exon junction complex,” Genes and Development, vol. 21, no. 16, pp. 1993–1998, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Sun, H. A. Perlick, H. C. Dietz, and L. E. Maquat, “A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 17, pp. 10009–10014, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. S. M. Medghalchi, P. A. Frischmeyer, J. T. Mendell, A. G. Kelly, A. M. Lawler, and H. C. Dietz, “Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability,” Human Molecular Genetics, vol. 10, no. 2, pp. 99–105, 2001. View at Scopus
  34. A. Yamashita, N. Izumi, I. Kashima et al., “SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay,” Genes and Development, vol. 23, no. 9, pp. 1091–1105, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. J. A. Holbrook, G. Neu-Yilik, M. W. Hentze, and A. E. Kulozik, “Nonsense-mediated decay approaches the clinic,” Nature Genetics, vol. 36, no. 8, pp. 801–808, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Kaygun and W. F. Marzluff, “Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1,” Nature Structural and Molecular Biology, vol. 12, no. 9, pp. 794–800, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Murakami, K. Yayama, L. Chao, and J. Chao, “Human kallikrein gene delivery protects against gentamycin-induced nephrotoxicity in rats,” Kidney International, vol. 53, no. 5, pp. 1305–1313, 1998. View at Publisher · View at Google Scholar · View at Scopus
  38. P. Federspil, “Clinical ototoxicity of gentamycin and its reversibility,” Archiv für Klinische und Experimentelle Ohren-, Nasen- und Kehlkopfheilkunde, vol. 196, no. 2, pp. 237–243, 1970. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Bhuvanagiri, A. M. Schlitter, M. W. Hentze, and A. E. Kulozik, “NMD: RNA biology meets human genetic medicine,” Biochemical Journal, vol. 430, no. 3, pp. 365–377, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. E. M. Coccia, C. Cicala, A. Charlesworth et al., “Regulation and expression of a growth arrest-specific gene (Gas5) during growth, differentiation, and development,” Molecular and Cellular Biology, vol. 12, no. 8, pp. 3514–3521, 1992. View at Scopus
  41. H. E. Gee, F. M. Buffa, C. Camps et al., “The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis,” British Journal of Cancer, vol. 104, no. 7, pp. 1168–1177, 2011. View at Publisher · View at Google Scholar · View at Scopus