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BioMed Research International
Volume 2013 (2013), Article ID 358945, 9 pages
A Comparative Study for the Evaluation of Two Doses of Ellagic Acid on Hepatic Drug Metabolizing and Antioxidant Enzymes in the Rat
1Department of Biology, Pamukkale University, Kinikli Campus, 20070 Denizli, Turkey
2Department of Biochemistry, Institute of Natural and Applied Science, Middle East Technical University, 06800 Ankara, Turkey
3Faculty of Art & Sciences, Biology Department, Pamukkale University, Kinikli, 20070 Denizli, Turkey
Received 15 April 2013; Accepted 4 June 2013
Academic Editor: Jason Shearer
Copyright © 2013 Gurbet Celik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- E. M. Daniel, A. S. Krupnick, Y.-H. Heur, J. A. Blinzler, R. W. Nims, and G. D. Stoner, “Extraction, stability, and quantitation of ellagic acid in various fruits and nuts,” Journal of Food Composition and Analysis, vol. 2, no. 4, pp. 338–349, 1989.
- H. Mukhtar, M. Das, and D. R. Bickers, “Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water,” Cancer Research, vol. 46, no. 5, pp. 2262–2265, 1986.
- S. Mandal, A. Ahuja, N. M. Shivapurkar, S. J. Cheng, J. D. Groopman, and G. D. Stoner, “Inhibition of aflatoxin B1 mutagenesis in Salmonella typhimurium and DNA damage in cultured rat and human tracheobronchial tissues by ellagic acid,” Carcinogenesis, vol. 8, no. 11, pp. 1651–1656, 1987.
- R. Dixit and B. Gold, “Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid,” Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 21, pp. 8039–8043, 1986.
- C. V. Rao, K. Tokumo, J. Rigotty, E. Zang, G. Kelloff, and B. S. Reddy, “Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, α-difluoromethylornithine, 16α-fluoro-5-androsten-17-one, and ellagic acid individually and in combination,” Cancer Research, vol. 51, no. 17, pp. 4528–4534, 1991.
- M. Boukharta, G. Jalbert, and A. Castonguay, “Biodistribution of ellagic acid and dose-related inhibition of lung tumorigenesis in A/J mice,” Nutrition and Cancer, vol. 18, no. 2, pp. 181–189, 1992.
- P. Lesca, “Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice,” Carcinogenesis, vol. 4, no. 12, pp. 1651–1653, 1983.
- M. Das, D. R. Bickers, and H. Mukhtar, “Effect of ellagic acid on hepatic and pulmonary xenobiotic metabolism in mice: studies on the mechanism of its anticarcinogenic action,” Carcinogenesis, vol. 6, no. 10, pp. 1409–1413, 1985.
- A. W. Wood, M. T. Huang, and R. L. Chang, “Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid,” Proceedings of the National Academy of Sciences of the United States of America, vol. 79, no. 18, pp. 5513–5517, 1982.
- S. Majid, K. L. Khanduja, R. K. Gandhi, S. Kapur, and R. R. Sharma, “Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice,” Biochemical Pharmacology, vol. 42, no. 7, pp. 1441–1445, 1991.
- D. H. Barch and C. C. Fox, “Selective inhibition of methylbenzylnitrosamine-induced formation of esophageal O6-methylguanine by dietary ellagic acid in rats,” Cancer Research, vol. 48, no. 24, pp. 7088–7092, 1988.
- H. Mukhtar, B. J. Del Tito Jr., and C. L. Marcelo, “Ellagic acid: a potent naturally occurring inhibitor of benzo[a]pyrene metabolism and its subsequent glucuronidation, sulfation and covalent binding to DNA in cultured BALB/c mouse keratinocytes,” Carcinogenesis, vol. 5, no. 12, pp. 1565–1571, 1984.
- H. U. Gali, E. M. Perchellet, and J.-P. Perchellet, “Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo,” Cancer Research, vol. 51, no. 11, pp. 2820–2825, 1991.
- A. W. Wood, D. S. Smith, R. L. Chang, M. T. Huang, and A. H. Conney, “Effects of flavonoids on the metabolism of xenobiotics,” Progress in Clinical and Biological Research, vol. 213, pp. 195–210, 1986.
- A. Sen and E. Arinç, “Preparation of highly purified cytochrome P4501A1 from leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular and immunochemical properties,” Comparative Biochemistry and Physiology C, vol. 121, no. 1–3, pp. 249–265, 1998.
- W.-G. Chung, A. Sen, J.-L. Wang-Buhler et al., “cDNA-directed expression of a functional zebrafish CYP1A in yeast,” Aquatic Toxicology, vol. 70, no. 2, pp. 111–121, 2004.
- L. Zou, M. R. Harkey, and G. L. Henderson, “Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity,” Life Sciences, vol. 71, no. 13, pp. 1579–1589, 2002.
- W. R. Miller, T. J. Anderson, and W. J. L. Jack, “Relationship between tumour aromatase activity, tumour characteristics and response to therapy,” Journal of Steroid Biochemistry and Molecular Biology, vol. 37, no. 6, pp. 1055–1059, 1990.
- R. W. Brueggemeier, J. A. Richards, S. Joomprabutra, A. S. Bhat, and J. L. Whetstone, “Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents,” Journal of Steroid Biochemistry and Molecular Biology, vol. 79, no. 1–5, pp. 75–84, 2001.
- L. S. Adams, Y. Zhang, N. P. Seeram, D. Heber, and S. Chen, “Pomegranate ellagitannin-derived compounds exhibit antiproferative and antiaromatase activity in breast cancer cells in vitro,” Cancer Prevention Research, vol. 3, no. 1, pp. 108–113, 2010.
- A. Rocha, L. Wang, M. Penichet, and M. Martins-Green, “Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer,” Breast Cancer Research and Treatment, vol. 136, pp. 647–658, 2012.
- J. D. Hayes and D. J. Pulford, “The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance,” Critical Reviews in Biochemistry and Molecular Biology, vol. 30, no. 6, pp. 445–600, 1995.
- V. P. Kelly, E. M. Ellis, M. M. Manson et al., “Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:Quinone oxidoreductase in rat liver,” Cancer Research, vol. 60, no. 4, pp. 957–969, 2000.
- N. Devipriya, A. R. Sudheer, and V. P. Menon, “Dose-response effect of ellagic acid on circulatory antioxidants and lipids during alcohol-induced toxicity in experimental rats,” Fundamental and Clinical Pharmacology, vol. 21, no. 6, pp. 621–630, 2007.
- N. A. El-Boghdady, “Protective effect of ellagic acid and pumpkin seed oil against methotrexate-induced small intestine damage in rats,” Indian Journal of Biochemistry and Biophysics, vol. 48, no. 6, pp. 380–387, 2011.
- M. A. Rosillo, M. Sanchez-Hidalgo, A. Cardeno et al., “Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats,” Pharmacological Research, vol. 66, pp. 235–242, 2012.
- A. Sen and A. Kirikbakan, “Biochemical characterization and distribution of glutathione S-transferases in leaping mullet (Liza saliens),” Biochemistry, vol. 69, no. 9, pp. 993–1000, 2004.
- P. K. Smith, R. I. Krohn, G. T. Hermanson et al., “Measurement of protein using bicinchoninic acid,” Analytical Biochemistry, vol. 150, no. 1, pp. 76–85, 1985.
- Y. Imai, A. Ito, and R. Sato, “Evidence for biochemically different types of vesicles in the hepatic microsomal fraction,” Journal of Biochemistry, vol. 60, no. 4, pp. 417–428, 1966.
- T. Nash, “The colorimetric estimation of formaldehyde by means of the Hantzsch reaction,” The Biochemical Journal, vol. 55, no. 3, pp. 416–421, 1953.
- J. Cochin and J. Axelrod, “Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine,” Journal of Pharmacology and Experimental Therapeutics, vol. 125, pp. 105–110, 1959.
- L. Kragie, S. D. Turner, C. J. Patten, C. L. Crespi, and D. M. Stresser, “Assessing pregnancy risks of azole antifungals using a high throughput aromatase inhibition assay,” Endocrine Research, vol. 28, no. 3, pp. 129–140, 2002.
- L. Ernster, “ DT diaphorase,” in Methods in Enzymology, R. W. Estabrook and M. E. Pullman, Eds., vol. 10, pp. 309–317, Academic Press, 1967.
- W. H. Habig, M. J. Pabst, and W. B. Jakoby, “Glutathione S transferases. The first enzymatic step in mercapturic acid formation,” Journal of Biological Chemistry, vol. 249, no. 22, pp. 7130–7139, 1974.
- H. Aebi, “Catalase,” in Method of Enzymatic Analysis, H. V. Bergrenyer, Ed., pp. 673–684, Academic Press, New York, NY, USA, 2nd edition, 1974.
- D. E. Paglia and W. N. Valentine, “Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase,” The Journal of Laboratory and Clinical Medicine, vol. 70, no. 1, pp. 158–169, 1967.
- U. K. Laemmli, “Cleavage of structural proteins during the assembly of the head of bacteriophage T4,” Nature, vol. 227, no. 5259, pp. 680–685, 1970.
- A.-L. Minn, H. Pelczar, C. Denizot et al., “Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa,” Drug Metabolism and Disposition, vol. 33, no. 8, pp. 1229–1237, 2005.
- H. H. Agus, P. Tekin, M. Bayav, A. Semiz, and A. Sen, “Drug interaction potential of the seed extract of Urtica urens L. (dwarf nettle),” Phytotherapy Research, vol. 23, no. 12, pp. 1763–1770, 2009.
- E. G. Giannini, R. Testa, and V. Savarino, “Liver enzyme alteration: a guide for clinicians,” Canadian Medical Association Journal, vol. 172, no. 3, pp. 367–379, 2005.
- D. H. Barch, L. M. Rundhaugen, P. E. Thomas, and P. Kardos, “Dietary ellagic acid inhibits the enzymatic activity of CYP1A1 without altering hepatic concentrations of CYP1A1 or CYP1A1 mRNA,” Biochemical and Biophysical Research Communications, vol. 201, no. 3, pp. 1477–1482, 1994.
- F. P. Guengerich, D.-H. Kim, and M. Iwasaki, “Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects,” Chemical Research in Toxicology, vol. 4, no. 2, pp. 168–179, 1991.
- D. R. Koop, “Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1,” Alcohol Research and Health, vol. 29, no. 4, pp. 274–280, 2006.
- T. Wilson, M. J. Lewis, K. L. Cha, and B. Gold, “The effect of ellagic acid on xenobiotic metabolism by cytochrome P-450IIE1 and nitrosodimethylamine mutagenicity,” Cancer Letters, vol. 61, no. 2, pp. 129–134, 1992.
- B. J. Song, “Gene structure and multiple regulations of the ethanol-inducible cytochrome P-4502E1 (CYP2EI) subfamily,” in Alcohol and Hormones, R. R. Watson, Ed., pp. 177–192, Totowa Humana Press, 1994.
- D. Farkas, L. E. Oleson, Y. Zhao et al., “Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice,” Journal of Clinical Pharmacology, vol. 47, no. 3, pp. 286–294, 2007.
- M. Hidaka, K.-I. Fujita, T. Ogikubo et al., “Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity,” Drug Metabolism and Disposition, vol. 32, no. 6, pp. 581–583, 2004.
- S. Ramos, “Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways,” Molecular Nutrition and Food Research, vol. 52, no. 5, pp. 507–526, 2008.
- M.-H. Pan and C.-T. Ho, “Chemopreventive effects of natural dietary compounds on cancer development,” Chemical Society Reviews, vol. 37, no. 11, pp. 2558–2574, 2008.
- D. Vauzour, A. Rodriguez-Mateos, G. Corona, M. J. Oruna-Concha, and J. P. E. Spencer, “Polyphenols and human health: prevention of disease and mechanisms of action,” Nutrients, vol. 2, no. 11, pp. 1106–1131, 2010.
- Y.-J. Surh and H.-K. Na, “NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals,” Genes and Nutrition, vol. 2, no. 4, pp. 313–317, 2008.
- P. J. Ansell, C. Espinosa-Nicholas, E. M. Curran et al., “In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens,” Endocrinology, vol. 145, no. 1, pp. 311–317, 2004.
- L. C. Appelt and M. M. Reicks, “Soy induces phase II enzymes but does not inhibit dimethylbenz[a]anthracene-induced carcinogenesis in female rats,” Journal of Nutrition, vol. 129, no. 10, pp. 1820–1826, 1999.
- W. A. Nijhoff, M. A. Bosboom, M. H. Smidt, and W. M. H. Peters, “Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by α-angelicalactone and flavone,” Carcinogenesis, vol. 16, no. 3, pp. 607–612, 1995.
- H. Wiegand, C. Boesch-Saadatmandi, I. Regos, D. Treutter, S. Wolffram, and G. Rimbach, “Effects of quercetin and catechin on hepatic glutathione-s transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and antioxidant enzyme activity levels in rats,” Nutrition and Cancer, vol. 61, no. 5, pp. 717–722, 2009.
- N. Doronicheva, H. Yasui, and H. Sakurai, “Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method,” Biological and Pharmaceutical Bulletin, vol. 30, no. 2, pp. 213–217, 2007.