A Comparative Study for the Evaluation of Two Doses of Ellagic Acid on Hepatic Drug Metabolizing and Antioxidant Enzymes in the Rat

Table 2

Changes of activities in liver of EA-treated rats.

	Control	10 mg/kg EA	Change (%)	30 mg/kg EA	Change (%)
EROD (pmol resorufin/min/mg prot.)	6.24 ± 2.23	6.53 ± 1.52	—	5.58 ± 3.97	11 ↓
MROD (pmol resorufin/min/mg prot.)	8.39 ± 2.49	8.31 ± 1.07	—	7.33 ± 3.40	13 ↓
C3ND (nmol HCHO/min/mg prot.)	0.40 ± 0.14	0.39 ± 0.02	—	0.24 ± 1.27*	40 ↓
EmND (nmol HCHO/min/mg prot.)	1.96 ± 0.35	1.78 ± 0.85	10 ↓	1.22 ± 0.09*	38 ↓
BPND (nmol HCHO/min/mg prot.)	1.47 ± 0.40	1.29 ± 0.61	13 ↓	0.662 ± 0.308*	55 ↓
BROD (pmol resorufin/min/mg prot.)	2.61 ± 0.86	2.23 ± 1.20	15 ↓	2.03 ± 1.39*	23 ↓
PROD (pmol resorufin/min/mg prot.)	6.51 ± 1.99	5.89 ± 0.907	10 ↓	4.60 ± 2.71*	30 ↓
APND (nmol HCHO/min/mg prot.)	0.339 ± 0.037	0.331 ± 0.031	—	0.154 ± 0.013*	55 ↓
A4H (nmol p-aminophenol/min/mg prot.)	0.344 ± 0.014	0.245 ± 0.08	28 ↓	0.145 ± 0.08*	58 ↓
NDMA (nmol HCHO/min/mg prot.)	0.405 ± 0.01	0.298 ± 0.11	26 ↓	0.114 ± 0.17*	56 ↓
ERND (nmol HCHO/min/mg prot.)	0.117 ± 0.027	0.124 ± 0.021	—	0.085 ± 0.045*	28 ↓
DBFOD (nmol fluorescein/min/mg prot.)	6.66 ± 0.138	6.15 ± 0.427	—	5.12 ± 1.84*	24 ↓
NQO1 (nmol/min/mg prot.)	184 ± 10.25	183 ± 9.49	—	541 ± 23.18*	194 ↑
GST-CDNB (nmol/min/mg prot.)	559 ± 56.71	561 ± 87.11	—	835 ± 13.08*	49 ↑
GST-DCNB (nmol/min/mg prot.)	12.99 ± 4.29	12.90 ± 8.15	—	18.45 ± 3.93*	42 ↑
GST-EA (nmol/min/mg prot.)	10.35 ± 1.61	10.32 ± 1.11	—	13.79 ± 3.22*	33 ↑
CAT (nmol/min/mg prot.)	9.33 ± 0.29	9.25 ± 0.33	—	15.37 ± 0.33*	64 ↑
GPX (nmol/min/mg prot.)	0.048 ± 0.004	0.05 ± 0.007	—	0.103 ± 0.003*	114 ↑

 *Significantly different from the respective control value, 𝑃<0.05.