Identifying the Association Rules between Clinicopathologic Factors and Higher Survival Performance in Operation-Centric Oral Cancer Patients Using the Apriori Algorithm

Table 1

Demographic data of 493 enrolled patients with OSCC.

Characteristics	Survived months			P value^∗1	5-year survival (%)	P value^∗2
	Total	>36 group	<36 group
Age				0.7786		0.5556
<30	7	3	4		71.4
30~50	228	125	103		77.2
50~70	236	129	107		79.2
>70	22	14	8		63.6
Primary Site				0.7915		0.1957
Lip	36	24	12		86.1
Cheek mucosa	184	103	81		83.2
Gum	42	25	17		71.4
Tongue	175	88	87		72.0
Mouth floor	19	11	8		68.4
Palate	5	3	2		60.0
Retromolar	27	15	12		77.8
Vestibule	2	1	1		100.0
Nonspecific	3	1	2		100.0
Laterality^*3				0.3965		0.8612
00	37	22	15		73.0
01	230	123	107		79.1
02	223	123	100		76.7
03	3	3	0		66.7
04	0	0	0		NA
Grade/differentiation				0.1476		0.0006
01	287	156	131		80.1
02	123	60	63		65.0
03	7	5	2		57.1
04	1	1	0		100.0
09	75	49	26		89.3
Regional lymph nodes examined				0.1550		0.1424
<5	285	160	125		80.4
>10	134	65	69		73.1
5~10	73	45	28		74.0
Clinical stage group				0.0749		0.5689
Stage 0	4	0	4		75.0
Stage 1	141	79	62		80.1
Stage 2	73	47	26		71.2
Stage 3	131	69	62		77.1
Stage 4	82	50	32		72.0
Pathologic stage group				0.2540		0.0514
Stage 0	2	2	0		100.0
Stage 1	215	112	103		82.3
Stage 2	92	52	40		75.0
Stage 3	31	15	16		74.2
Stage 4	58	24	34		67.2
Clinical tumor size				0.3967		0.0004
<2 cm	162	100	62		87.0
2~4 cm	244	134	110		71.3
>4 cm	33	19	14		66.7
Pathology tumor size				0.4417		0.0141
<2 cm	197	114	83		81.7
2~4 cm	183	94	89		69.4
>4 cm	25	14	11		72.0
OP group^*4				<0.0001		<0.0001
01	385	238	147		81.6
02	27	14	13		66.7
03	81	19	62		61.7

^∗1𝑃 value for the comparison of the survival between >36 and <36 months groups.
^∗2𝑃 value for 5-year survival among the items of the same characteristics group.
∗30: unknown primary site or the shape of the organ is not paired; 1: the primary site is originated from the right side; 2: the primary site is originated from the left side; 3: only one side is invaded but it is not clear which side (R't or L't) it is originated from; 4: both sides are invaded but the origin of the primary site is not clear and the chart record describes only one primary site.
∗4OP group for 01: OP only; 02: OP→IA; 03: OP→CT, OP→CT + IV, OP→CT→RT, OP→IA→RT, OP→IV,OP→IV→RT, OP→RT, OP→RT + CT,OP→RT + IV, OP→RT→CT, OP→RT→IA, OP→RT→IV. Symbols: OP: operation; IA: intraarterial chemotherapy; CT: oral chemotherapy; IV: intravenous chemotherapy; RT: radiotherapy; →: then.