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BioMed Research International
Volume 2013 (2013), Article ID 361906, 15 pages
Activation of the ERK1/2 Signaling Pathway during the Osteogenic Differentiation of Mesenchymal Stem Cells Cultured on Substrates Modified with Various Chemical Groups
1Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110001, China
2State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
3Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
Received 22 April 2013; Revised 9 July 2013; Accepted 16 July 2013
Academic Editor: Kibret Mequanint
Copyright © 2013 Bing Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. Buma, W. Schreurs, and N. Verdonschot, “Skeletal tissue engineering—from in vitro studies to large animal models,” Biomaterials, vol. 25, no. 9, pp. 1487–1495, 2004.
- M. F. Pittenger, A. M. Mackay, S. C. Beck et al., “Multilineage potential of adult human mesenchy-mal stem cells,” Science, vol. 284, no. 5411, pp. 143–147, 1999.
- D. Dallari, M. Fini, C. Stagni et al., “In vivo study on the healing of bone defects treated with bone marrow stromal cells, platelet-rich plasma, and freeze-dried bone allografts, alone and in combination,” Journal of Orthopaedic Research, vol. 24, no. 5, pp. 877–888, 2006.
- M. P. Lutolf, P. M. Gilbert, and H. M. Blau, “Designing materials to direct stem-cell fate,” Nature, vol. 462, no. 7272, pp. 433–441, 2009.
- C. Chai and K. W. Leong, “Biomaterials approach to expand and direct differentiation of stem cells,” Molecular Therapy, vol. 15, no. 3, pp. 467–480, 2007.
- K. Saha, J. F. Pollock, D. V. Schaffer, and K. E. Healy, “Designing synthetic materials to control stem cell phenotype,” Current Opinion in Chemical Biology, vol. 11, no. 4, pp. 381–387, 2007.
- E. Dawson, G. Mapili, K. Erickson, S. Taqvi, and K. Roy, “Biomaterials for stem cell differentiation,” Advanced Drug Delivery Reviews, vol. 60, no. 2, pp. 215–228, 2008.
- S. M. Dellatore, A. S. Garcia, and W. M. Miller, “Mimicking stem cell niches to increase stem cell expansion,” Current Opinion in Biotechnology, vol. 19, no. 5, pp. 534–540, 2008.
- L. Little, K. E. Healy, and D. Schaffer, “Engineering biomaterials for synthetic neural stem cell microenvironments,” Chemical Reviews, vol. 108, no. 5, pp. 1787–1796, 2008.
- J. A. Burdick and G. Vunjak-Novakovic, “Engineered microenvironments for controlled stem cell differentiation,” Tissue Engineering A, vol. 15, no. 2, pp. 205–219, 2009.
- R. A. Marklein and J. A. Burdick, “Controlling stem cell fate with material design,” Advanced Materials, vol. 22, no. 2, pp. 175–189, 2010.
- B. G. Keselowsky, D. M. Collard, and A. J. García, “Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion,” Journal of Biomedical Materials Research A, vol. 66, no. 2, pp. 247–259, 2003.
- B. G. Keselowsky, D. M. Collard, and A. J. García, “Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding,” Biomaterials, vol. 25, no. 28, pp. 5947–5954, 2004.
- M. A. Lan, C. A. Gersbach, K. E. Michael, B. G. Keselowsky, and A. J. García, “Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries,” Biomaterials, vol. 26, no. 22, pp. 4523–4531, 2005.
- G. Xiao, D. Jiang, P. Thomas et al., “MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1,” Journal of Biological Chemistry, vol. 275, no. 6, pp. 4453–4459, 2000.
- G. Xiao, R. Gopalakrishnan, D. Jiang, E. Reith, M. D. Benson, and R. T. Franceschi, “Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells,” Journal of Bone and Mineral Research, vol. 17, no. 1, pp. 101–110, 2002.
- L. Chang and M. Karin, “Mammalian MAP kinase signalling cascades,” Nature, vol. 410, no. 6824, pp. 37–40, 2001.
- Q. Liu, L. Cen, H. Zhou et al., “The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone,” Tissue Engineering A, vol. 15, no. 11, pp. 3487–3497, 2009.
- R. K. Jaiswal, N. Jaiswal, S. P. Bruder, G. Mbalaviele, D. R. Marshak, and M. F. Pittenger, “Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase,” Journal of Biological Chemistry, vol. 275, no. 13, pp. 9645–9652, 2000.
- E. M. Sale, P. G. P. Atkinson, and G. J. Sale, “Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis,” EMBO Journal, vol. 14, no. 4, pp. 674–684, 1995.
- R. M. Salasznyk, R. F. Klees, M. K. Hughlock, and G. E. Plopper, “ERK signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells on collagen I and vitronectin,” Cell Communication and Adhesion, vol. 11, no. 5-6, pp. 137–153, 2004.
- L. Fu, T. Tang, Y. Miao, S. Zhang, Z. Qu, and K. Dai, “Stimulation of osteogenic differentiation and inhibition of adipogenic differentiation in bone marrow stromal cells by alendronate via ERK and JNK activation,” Bone, vol. 43, no. 1, pp. 40–47, 2008.
- M. Mrksich, “Using self-assembled monolayers to model the extracellular matrix,” Acta Biomaterialia, vol. 5, no. 3, pp. 832–841, 2009.
- J. M. Curran, R. Chen, and J. A. Hunt, “The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate,” Biomaterials, vol. 27, no. 27, pp. 4783–4793, 2006.
- J. M. Curran, R. Chen, and J. A. Hunt, “Controlling the phenotype and function of mesenchymal stem cells in vitro by adhesion to silane-modified clean glass surfaces,” Biomaterials, vol. 26, no. 34, pp. 7057–7067, 2005.
- J. E. Phillips, T. A. Petrie, F. P. Creighton, and A. J. García, “Human mesenchymal stem cell differentiation on self-assembled monolayers presenting different surface chemistries,” Acta Biomaterialia, vol. 6, no. 1, pp. 12–20, 2010.
- Y.-J. Ren, H. Zhang, H. Huang et al., “in vitro behavior of neural stem cells in response to different chemical functional groups,” Biomaterials, vol. 30, no. 6, pp. 1036–1044, 2009.
- J. M. Curran, F. Pu, R. Chen, and J. A. Hunt, “The use of dynamic surface chemistries to control msc isolation and function,” Biomaterials, vol. 32, no. 21, pp. 4753–4760, 2011.
- X. Liu, J. He, S. Zhang, X. M. Wang, H. Y. Liu, and F. Z. Cui, “Adipose stem cells controlled by surface chemistry,” Journal of Tissue Engineering and Regenerative Medicin, vol. 7, no. 2, pp. 112–117, 2013.
- X.-L. Yu, B. Zhang, X.-M. Wang et al., “Cancer cell proliferation controlled by surface chemistry in its microenvironment,” Frontiers of Materials Science, vol. 5, no. 4, pp. 412–416, 2011.
- H. Deng, X. Wang, C. Du, X.-C. Shen, and F.-Z. Cui, “Combined effect of ion concentration and functional groups on the surface chemistry modulated CaCO3 crystallization,” CrystEngComm, vol. 20, no. 14, pp. 6647–6653, 2012.
- G. K. Toworfe, R. J. Composto, I. M. Shapiro, and P. Ducheyne, “Nucleation and growth of calcium phosphate on amine-, carboxyl- and hydroxyl-silane self-assembled monolayers,” Biomaterials, vol. 27, no. 4, pp. 631–642, 2006.
- C. A. Widrig, C. A. Alves, and M. D. Porter, “Scanning tunneling microscopy of ethanethiolate and n-octadecanethiolate monolayers spontaneously adsorbed at gold surfaces,” Journal of the American Chemical Society, vol. 113, no. 8, pp. 2805–2810, 1991.
- S. Lossdörfer, Z. Schwartz, C. H. Lohmann, D. C. Greenspan, D. M. Ranly, and B. D. Boyan, “Osteoblast response to bioactive glasses in vitro correlates with inorganic phosphate content,” Biomaterials, vol. 25, no. 13, pp. 2547–2555, 2004.
- F. Otto, A. P. Thornell, T. Crompton et al., “Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development,” Cell, vol. 89, no. 5, pp. 765–771, 1997.
- G. Karsenty, “Role of Cbfa1 in osteoblast differentiation and function,” Seminars in Cell and Developmental Biology, vol. 11, no. 5, pp. 343–346, 2000.
- A. K. Kundu, C. B. Khatiwala, and A. J. Putnam, “Extracellular matrix remodeling, integrin expression, and downstream signaling pathways influence the osteogenic differentiation of mesenchymal stem cells on poly(Lactide-co-glycolide) substrates,” Tissue Engineering A, vol. 15, no. 2, pp. 273–283, 2009.
- R. O. Hynes, “Integrins: versatility, modulation, and signaling in cell adhesion,” Cell, vol. 69, no. 1, pp. 11–25, 1992.
- E. Ruoslahti, “Integrins,” Journal of Clinical Investigation, vol. 87, no. 1, pp. 1–5, 1991.
- E. A. Clark and J. S. Brugge, “Integrins and sign transduction pathways: the road taken,” Science, vol. 268, no. 5208, pp. 233–239, 1995.
- R. O. Hynes, “Integrins: bidirectional, allosteric signaling machines,” Cell, vol. 110, no. 6, pp. 673–687, 2002.
- A. Krause, E. A. Cowles, and G. Gronowicz, “Integrin-mediated signaling in osteoblasts on titanium implant materials,” Journal of Biomedical Materials Research, vol. 52, no. 4, pp. 738–747, 2000.
- L. Pang, T. Sawada, S. J. Decker, and A. R. Saltiel, “Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor,” Journal of Biological Chemistry, vol. 270, no. 23, pp. 13585–13588, 1995.
- M. R. Caplan and M. M. Shah, “Translating biomaterial properties to intracellular signaling,” Cell Biochemistry and Biophysics, vol. 54, no. 1–3, pp. 1–10, 2009.
- J. G. Lock, B. Wehrle-Haller, and S. Strömblad, “Cell-matrix adhesion complexes: master control machinery of cell migration,” Seminars in Cancer Biology, vol. 18, no. 1, pp. 65–76, 2008.
- I. Delon and N. H. Brown, “Integrins and the actin cytoskeleton,” Current Opinion in Cell Biology, vol. 19, no. 1, pp. 43–50, 2007.
- A. L. Berrier and K. M. Yamada, “Cell-matrix adhesion,” Journal of Cellular Physiology, vol. 213, no. 3, pp. 565–573, 2007.
- R. L. Juliano, P. Reddig, S. Alahari, M. Edin, A. Howe, and A. Aplin, “Integrin regulation of cell signalling and motility,” Biochemical Society Transactions, vol. 32, no. 3, pp. 443–446, 2004.
- F. G. Giancotti and E. Ruoslahti, “Integrin signaling,” Science, vol. 285, no. 5430, pp. 1028–1032, 1999.
- R. O. Hynes, “Integrins: a family of cell surface receptors,” Cell, vol. 48, no. 4, pp. 549–554, 1987.
- J. W. Ramos, “The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells,” International Journal of Biochemistry and Cell Biology, vol. 40, no. 12, pp. 2707–2719, 2008.
- J. P. Rodríguez, S. Ríos, M. Fernández, and J. F. Santibañez, “Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women,” Journal of Cellular Biochemistry, vol. 92, no. 4, pp. 745–754, 2004.
- R. F. Klees, R. M. Salasznyk, K. Kingsley, W. A. Williams, A. Boskey, and G. E. Plopper, “Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway,” Molecular Biology of the Cell, vol. 16, no. 2, pp. 881–890, 2005.
- N. Takahashi, Y. Seko, E. Noiri et al., “Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes,” Circulation Research, vol. 84, no. 10, pp. 1194–1202, 1999.
- S. Klein, F. G. Giancotti, M. Presta, S. M. Albelda, C. A. Buck, and D. B. Rifkin, “Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells,” Molecular Biology of the Cell, vol. 4, no. 10, pp. 973–982, 1993.
- R. F. Rotundo, T. M. Curtis, M. D. Shah et al., “TNF-α disruption of lung endothelial integrity: reduced integrin mediated adhesion to fibronectin,” American Journal of Physiology. Lung Cellular and Molecular Physiology, vol. 282, no. 2, pp. L316–L329, 2002.
- C.-H. Yeh, H.-C. Peng, and T.-F. Huang, “Cytokines modulate integrin α(v)β3-mediated human endothelial cell adhesion and calcium signaling,” Experimental Cell Research, vol. 251, no. 1, pp. 57–66, 1999.
- H.-Y. Liu, X. Liu, L.-P. Zhang, H.-J. Ai, and F.-Z. Cui, “Improvement on the performance of bone regeneration of calcium sulfate hemihydrate by adding mineralized collagen,” Tissue Engineering A, vol. 16, no. 6, pp. 2075–2084, 2010.
- C. A. Scotchford, C. P. Gilmore, E. Cooper, G. J. Leggett, and S. Downes, “Protein adsorption and human osteoblast-like cell attachment and growth on alkylthiol on gold self-assembled monolayers,” Journal of Biomedical Materials Research, vol. 59, no. 1, pp. 84–99, 2002.
- N. Faucheux, R. Schweiss, K. Lützow, C. Werner, and T. Groth, “Self-assembled monolayers with different terminating groups as model substrates for cell adhesion studies,” Biomaterials, vol. 25, no. 14, pp. 2721–2730, 2004.
- D. E. Ingber, “Tensegrity II. How structural networks influence cellular information processing networks,” Journal of Cell Science, vol. 116, no. 8, pp. 1397–1408, 2003.
- G. Altankov, F. Grinnell, and T. Groth, “Studies on the biocompatibility of materials: fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability,” Journal of Biomedical Materials Research, vol. 30, no. 3, pp. 385–391, 1996.
- S. Gronthos, P. J. Simmons, S. E. Graves, and P. G. Robey, “Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix,” Bone, vol. 28, no. 2, pp. 174–181, 2001.
- K. Webb, V. Hlady, and P. A. Tresco, “Relationships among cell attachment, spreading, cytoskeletal organization, and migration rate for anchorage-dependent cells on model surfaces,” Journal of Biomedical Materials Research, vol. 49, no. 3, pp. 362–368, 2000.
- R. Zaidel-Bar, S. Itzkovitz, A. Ma'ayan, R. Iyengar, and B. Geiger, “Functional atlas of the integrin adhesome,” Nature Cell Biology, vol. 9, no. 8, pp. 858–867, 2007.
- L. B. Rosen, D. D. Ginty, M. J. Weber, and M. E. Greenberg, “Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras,” Neuron, vol. 12, no. 6, pp. 1207–1221, 1994.