Figure 1: Macroscopic histomorphological evaluation of bladders. All the bladders from the Control (a) and -3-treated-rats (b) revealed a normal appearance. In the BBN group (c), 65.0% of the rats exhibited exuberant bladder cancer occupying almost the vesical lumen. In this group, the bladders showed a remarkable hypervascularization, suggesting neoangiogenesis, characteristic of tumor growth. In the preventive -3 + BBN group (d), identical percentage of tumors was found but with an outstanding reduction of tumor volume.