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BioMed Research International
Volume 2013 (2013), Article ID 368975, 12 pages
http://dx.doi.org/10.1155/2013/368975
Research Article

Genome-Wide Analysis of Human MicroRNA Stability

1Department of Cell Biology, Stem Cell Research Center, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing 100191, China
2Department of Integrated Chinese and Western Medicine, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing 100191, China
3Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing 100191, China
4MOE Key Lab of Molecular Cardiovascular Science, Peking University, 38 Xueyuan Road, Beijing 100191, China
5Department of Biomedical Informatics, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing 100191, China

Received 18 July 2013; Accepted 26 August 2013

Academic Editor: Edwin Wang

Copyright © 2013 Yang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure S1: Relationships among the ten cells linked by significant correlation (A) and mapped on a 2-dimensional Euclidean space by multidimensional scaling (MDS) based on miRNA stability data (B). For the cell network (A), a red link means a significant positive correlation (P<=0.05) of miRNA stability between the two linked cell lines, whereas a blue link means a significant negative correlation (P<=0.05).

Supplementary Figure S2: Comparison of miRNA stability (miRNA stability index, MSI) between miRNAs that responde to environmental factor (EF, red bar) and miRNAs that are not reported to respond EF (nonEF, green bar) in the MCF-7 cell.

  1. Supplementary Figures