PDZ Domains and Viral Infection: Versatile Potentials of HPV-PDZ Interactions in relation to Malignancy

Figure 1

The E6 proteins of high-risk or oncogenic HPVs uniquely contain class I -PBM (sequence x-S/T-x-V/I/L-COOH) located at the C-terminus. Representative alignment of the C-terminal ends of the E6 proteins from the most frequently found. HPV types associated with cervical carcinoma (HPV 16, 33, 18, 45, 31, 35, 56) and compared with low risk types (HPV 6, 11, 42, 44). PKA consensus motif (RRxT) marked in purple.