Enhanced Therapeutic Efficacy of iRGD-Conjugated Crosslinked Multilayer Liposomes for Drug Delivery
Figure 1
Characterization, release profile, and conjugation of iRGD-cMLVs. (a) Schematic illustration of the synthesis of iRGD-conjugated crosslinked multilamellar vesicle (iRGD-cMLV). (b) The hydrodynamic size distribution of iRGD-cMLVs measured by dynamic light scattering (DLS). Data represented the mean ± SD of at least three experiments with . (c) In vitro release kinetics of doxorubicin (Dox) from iRGD-cMLVs. Error bars represent standard error of the mean; for each formulation. ((d), (e)) Confirmation of the conjugation of iRGD peptides onto the cMLV nanoparticles by confocal imaging. DiD-labeled iRGD-cMLVs (d) and DiD-labeled cMLVs (e) were reacted with Alexa488 dye for 1 h at room temperature followed by confocal imaging. Scale bar represents 5 μm.
