Figure 3: Effect of edaravone on TBI after CCI based on TB staining. (a) Representative core- (upper) and peri-injury (lower) images of TB staining 24 hours after CCI. The region with little or no staining was defined as the injury area. Edaravone () was injected at 0, 3, or 6 hours and vehicle () at 0 hours after CCI. The total (b) or core- and peri-injury (c) areas were semiquantified in each experimental group. Data are expressed as mean ± SEM. Asterisk (*) indicates a significant difference between the groups based on Tukey-Kramer tests.