Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

Table 2

Molecular targets of pinocembrin in different cancer types.

Cancer types	Cell lines	IC50/concentration	Major targets	References
Colon	HCT-116, HT-29	26.33 to 143.09 µg mL^−1; 1.6 to 13.6 μM	Superoxide anion radical↓, Bax↑, NO2↓, ΔΨm↓	[24, 111, 112]
Leukaemia	HL-60	IC50 < 100 ng/mL	Fas↑, FasL↑, caspase-3/8/9↑, tBid↑	[100, 113]

↓: downregulation; ↑: upregulation.