About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 382058, 7 pages
http://dx.doi.org/10.1155/2013/382058
Research Article

Dehydroepiandrosterone Protects Endothelial Cells against Inflammatory Events Induced by Urban Particulate Matter and Titanium Dioxide Nanoparticles

1Departamento de Biología Celular, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Colonia Sección 16, Tlalpan, 14080 México, DF, Mexico
2Departamento de Posgrado. Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico
3Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico

Received 5 September 2012; Revised 30 November 2012; Accepted 6 December 2012

Academic Editor: Per Schwarze

Copyright © 2013 Elizabeth Huerta-García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. J. Delfino, C. Sioutas, and S. Malik, “Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health,” Environmental Health Perspectives, vol. 113, no. 8, pp. 934–946, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Stone, H. Johnston, and M. J. D. Clift, “Air pollution, ultrafine and nanoparticle toxicology: cellular and molecular interactions,” IEEE Transactions on Nanobioscience, vol. 6, no. 4, pp. 331–340, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Montiel-Dávalos, E. Alfaro-Moreno, and R. López-Marure, “PM2.5 and PM10 induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells,” Inhalation Toxicology, vol. 19, no. 1, pp. 91–98, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Alfaro-Moreno, R. López-Marure, A. Montiel-Dávalos et al., “E-Selectin expression in human endothelial cells exposed to PM10: the role of endotoxin and insoluble fraction,” Environmental Research, vol. 103, no. 2, pp. 221–228, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Montiel-Dávalos, M. J. Ibarra-Sánchez, J. L. Ventura-Gallegos, et al., “Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter,” Toxicology in Vitro, vol. 24, no. 1, pp. 135–141, 2010.
  6. A. Montiel-Dávalos, J. L. Ventura-Gallegos, E. Alfaro-Moreno, et al., “TiO2 nanoparticles induce dysfunction and activation of human endothelial cells,” Chemical Research Toxicology, vol. 25, no. 4, pp. 920–930, 2012.
  7. G. Gutiérrez, C. Mendoza, E. Zapata et al., “Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells,” Atherosclerosis, vol. 190, no. 1, pp. 90–99, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. R. López-Marure, C. Huesca-Gómez, M. D. J. Ibarra-Sánchez, A. Zentella, and O. Pérez-Méndez, “Dehydroepiandrosterone delays LDL oxidation in vitro and attenuates several oxLDL-induced inflammatory responses in endothelial cells,” Inflammation and Allergy—Drug Targets, vol. 6, no. 3, pp. 174–182, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Alfaro-Moreno, L. Martínez, C. García-Cuellar, et al., “Biological effects induced in vitro by PM10 from three different zones of Mexico City,” Environment Health Perspectives, vol. 110, no. 7, pp. 715–772, 2002.
  10. A. M. Curatola, K. Huang, and F. Naftolin, “Dehydroepiandrosterone (DHEA) inhibition of monocyte binding by vascular endothelium is associated with sialylation of neural cell adhesion molecule,” Reproductive Sciences, vol. 19, no. 1, pp. 86–91, 2012.
  11. E. 1. Huerta-García, J. L. Ventura-Gallegos, M. E. Victoriano, et al., “Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration,” Steroids, vol. 77, no. 3, pp. 233–240, 2012.
  12. P. J. A. Borm, D. Robbins, S. Haubold et al., “The potential risks of nanomaterials: a review carried out for ECETOC,” Particle and Fibre Toxicology, vol. 3, article 11, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Yamada, M. Sakuma, and T. Suga, “Induction of peroxisomal β-oxidation enzymes by dehydroepiandrosterone and its sulfate in primary cultures of rat hepatocytes,” Biochimica et Biophysica Acta, vol. 1137, no. 2, pp. 231–236, 1992. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Swierczynski, P. Bannasch, and D. Mayer, “Increase of lipid peroxidation in rat liver microsomes by dehydroepiandrosterone feeding,” Biochimica et Biophysica Acta, vol. 1315, no. 3, pp. 193–198, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Gallo, M. Aragno, V. Gatto et al., “Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line,” European Journal of Endocrinology, vol. 141, no. 1, pp. 35–39, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. M. D. Kraaij, S. W. van der Kooij, M. E. Reinders, et al., “Dexamethasone increases ROS production and T cell suppressive capacity by anti-inflammatory macrophages,” Molecular Immunology, vol. 49, no. 3, pp. 549–557, 2011.
  17. G. Bjelaković, S. Beninati, D. Pavlović, et al., “Glucocorticoids and oxidative stress,” Journal of Basic and Clinical Physiology and Pharmacology, vol. 18, no. 2, pp. 115–112, 2007.
  18. A. M. Traish, H. P. Kang, F. Saad, et al., “Dehydroepiandrosterone (DHEA)-a precursor steroid or an active hormone in human physiology,” Journal of Sexual Medicine, vol. 8, no. 11, pp. 2960–2982, 2011.
  19. C. Young Shin, J. W. Choi, E. Sook Jang et al., “Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose,” Brain Research, vol. 922, no. 2, pp. 267–275, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Brignardello, M. Gallo, M. Aragno et al., “Dehydroepiandrosterone prevents lipid peroxidation and cell growth inhibition induced by high glucose concentration in cultured rat mesangial cells,” Journal of Endocrinology, vol. 166, no. 2, pp. 401–406, 2000. View at Scopus
  21. J. P. G. Camporez, E. H. Akamine, A. P. Davel, C. R. Franci, L. V. Rossoni, and C. R. De Oliveira Carvalho, “Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats,” Journal of Physiology, vol. 589, no. 10, pp. 2585–2596, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Aragno, G. Meineri, I. Vercellinatto et al., “Cardiac impairment in rabbits fed a high-fat diet is counteracted by dehydroepiandrosterone supplementation,” Life Sciences, vol. 85, no. 1-2, pp. 77–84, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Chakraborti, K. Gulati, and A. Ray, “Involvement of nitric oxide in the protective effects of dehydroepiandrosterone sulphate on stress induced neurobehavioral suppression and brain oxidative injury in rats,” European Journal of Pharmacology, vol. 652, no. 1–3, pp. 55–59, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. M. A. Pelissier, C. Trap, M. I. Malewiak, and R. Morfin, “Antioxidant effects of dehydroepiandrosterone and 7α-hydroxy- dehydroepiandrosterone in the rat colon, intestine and liver,” Steroids, vol. 69, no. 2, pp. 137–144, 2004. View at Publisher · View at Google Scholar · View at Scopus