Review Article
Meta-Analysis of Cytokine Gene Polymorphisms and Outcome of Heart Transplantation
Table 1
Characteristic of studies which were included in meta-analysis.
| Author, year | No. of subjects | Country | Design | Mean age | Percent male | Immunosuppressive agents | HLA | Outcome |
| Azzawi et al. 2001 [11] | 119 | United Kingdom | Cohort | | | Cyclosporine (4–12 mg/kg/day) Azathioprine (1-2 mg/kg/day) Prednisolone (0.1–0.2 mg/kg/day) | Not based on HLA matching | AGR/CGR | Bijlsma et al. 2002 [6] | 70 | The Netherlands | Cohort | | | | | AGR | Plaza et al. 2003 [10] | 71 | Columbia | Cohort | 45.6 | 83.1 | Cyclosporine, prednisolone, and azathioprine | Complete match | | Gourley et al. 2004 [8] | 92 | Pennsylvania | Cohort | 52.0 | 79.0 | Cyclosporine, prednisone, and azathioprine/mycophenolate mofetil | 87% had >3 mismatch | AGR | McDaniel et al. 2004 [9] | 55* | Mississippi | Cohort | — | 76.0 | | | AGR | Filippo et al. 2006 [7] | 111 | Pittsburgh | Cohort | 7.5 | 56.8 | Tacrolimus/cyclosporine, and corticosteroid | — | AGR/CGR | Girnita et al. 2008 [12] | 322 | Washington | Cohort | 5.3 | 57.0 | — | — | AGR/CGR |
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AGR: acute graft rejection; CGR: chronic graft rejection. Authors provided data.
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