Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas

Figure 3

Measles virus exhibits oncolytic properties against human adenocarcinomas in vivo. (a) Nude mice were challenged subcutaneously with 1 million A549 (lung) or Caco-2 (colorectal) human adenocarcinoma cells. When tumors reached a volume of 100 mm³ for A549 or 150–200 mm³ for Caco-2, MV-eGFP or PBS was injected intratumorally (day 0, 1.5 × 10⁷ TCID₅₀). Tumor volumes were measured twice weekly. Additional intratumoral MV injections were performed with A549 mice at days 22, 28, and 35 after initial injection as indicated by arrowheads. (b) When tumors reach 1–1.5 cm³ or after 31 (Caco-2 tumor) or 42 (A549 tumors) days, animals were sacrificed and tumors were harvested and weighed. (*𝑃<0.05; **𝑃<0.01).

(a)

(b)