High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy

Figure 4

Correlation between expressions of H3K27me3 and EZH2 in UCB tissues. (a) High expression for EZH2 was observed in a UCB (case 86), in which more than 70% of tumor cells showed nuclear positive staining of EZH2 protein (400X). (b) Overexpression of H3K27me3 was examined in the same UCB case 86 (400X). (c) In 59 UCB cases with high expression of H3K27me3, an average of 61.0% of the UCB cells stained positive with EZH2, a percentage of cancer cells that was significantly larger than that (46.3%) in 67 UCBs with low expression of H3K27me3 (𝑃=0.003, independent sample 𝑡 test).

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