High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy
Table 1
Association between the expression of H3K27me3 and clinicopathologic features in UCB.
Characteristic
Total cases
H3K27me3 expression (%)
Low expression
High expression
value*
Age (years)
0.955
≤65**
68
36 (52.9)
32 (47.1)
>65
58
31 (53.4)
27 (46.6)
Gender
0.817
Male
114
61 (53.5)
53 (46.5)
Female
12
6 (50.0)
6 (50.0)
Tumor multiplicity
0.010
Unifocal
49
19 (38.8)
30 (61.2)
Multifocal
77
48 (62.3)
29 (37.7)
WHO grade
0.312
G1
24
16 (66.7)
8 (33.3)
G2
46
24 (52.2)
22 (47.8)
G3
56
27 (48.2)
29 (51.8)
pT status
0.404
PT1
25
16 (64.0)
9 (36.0)
PT2
55
30 (54.5)
25 (45.5)
PT3
30
15 (50.0)
15 (50.0)
PT4
16
6 (37.5)
10 (62.5)
pN status
0.046
PN−
105
60 (57.1)
45 (42.9)
PN+
21
7 (33.3)
14 (66.7)
Chi-square test; **median age; UCB: urothelial carcinoma of bladder.
