High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy
Table 2
Univariate analysis of H3K27m3 expression and various clinicopathological parameters in 126 patients with UCB.
Characteristic
Total cases
RR (95% CI)
value
Age, years
0.786
≤65*
68
1
>65
58
1.090 (0.586–2.027)
Gender
0.675
Male
114
1
Female
12
0.777 (0.239–2.523)
Tumor multiplicity
0.026
Unifocal
49
1
Multifocal
77
2.025 (1.088–3.771)
WHO grade
0.330
G1
24
1
G2
46
2.069 (0.757–5.655)
G3
56
2.016 (0.751–5.412)
pT status
<0.001
PT1
25
1
PT2
55
1.047 (0.363–3.017)
PT3
30
2.561 (0.908–7.219)
PT4
16
6.577 (2.250–19.227)
pN status
<0.001
PN−
105
1
PN+
21
4.957 (2.573–9.549)
H3K27me3
<0.001
Low expression
67
1
High expression
59
6.476 (2.857–14.676)
Median age; RR: relative risk; CI: confidence interval; UCB: urothelial carcinoma of bladder.
