Dantrolene-Induced Inhibition of Skeletal L-Type Ca²⁺ Current Requires RyR1 Expression

Figure 3

Tail current analysis. (a) Comparison of peak 𝐼-𝑉 relationships for control (⚫; 𝑛=20) and Dantrolene-treated (⚪; 𝑛=10) myotubes. Tail currents were elicited by repolarization from the indicated test potential to −80 mV. Currents were evoked at 0.1 Hz by test potentials ranging from −70 mV through +40 mV in 10 mV increments. Peak tail current amplitudes were normalized by linear cell capacitance (pA/pF).