Research Article

A Combination of Radiosurgery and Soluble Tissue Factor Enhances Vascular Targeting for Experimental Glioblastoma

Figure 3

Radiosurgery induced externalization of phosphatidylserine from the surface of endothelial cells of GBM capillaries. (a) Positive immunofluorescent staining of specific endothelial cell marker, von Willebrand factor, on the surface of endothelial cells of GBM capillaries in mice that received radiosurgery. (b) Positive immunofluorescent staining of phosphatidylserine on the surface of endothelial cells of GBM capillaries in mice that received radiosurgery. (c) Weak immunofluorescent staining of phosphatidylserine on the surface of endothelial cells of GBM capillaries in mice that received sham radiosurgery. (d) Time course of immunofluorescent intensity of phosphatidylserine on the surface of endothelial cells of GBM capillaries in mice that received sham radiosurgery (−1 day) or radiosurgery over a period of 42 days. There is a negative correlation between time and the immunofluorescent intensity of phosphatidylserine on the surface of endothelial cells of GBM capillaries in mice that received radiosurgery over a period of 42 days ( ,   ). paired comparison between before (−1 day) and after radiosurgery at different time points. L, lumen.
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