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BioMed Research International
Volume 2013 (2013), Article ID 390714, 11 pages
A Combination of Radiosurgery and Soluble Tissue Factor Enhances Vascular Targeting for Experimental Glioblastoma
1Australian School of Advanced Medicine, Macquarie University, 2 Technology Place, North Ryde, Sydney, NSW 2109, Australia
2Department of Neurosurgery, The 9th Medical Clinical College of Beijing University, Beijing 100850, China
3Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing 100038, China
Received 28 April 2013; Accepted 25 September 2013
Academic Editor: Pasquale F. Innominato
Copyright © 2013 Jian Tu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. A. Rosenthal, K. J. Drummond, M. Dally et al., “Management of glioma in Victoria (1998-2000): retrospective cohort study,” Medical Journal of Australia, vol. 184, no. 6, pp. 270–273, 2006.
- N. G. Burnet, S. J. Jefferies, R. J. Benson, D. P. Hunt, and F. P. Treasure, “Years of life lost (YLL) from cancer is an important measure of population burden and should be considered when allocating research funds,” British Journal of Cancer, vol. 92, no. 2, pp. 241–245, 2005.
- P. Y. Wen and S. Kesari, “Malignant gliomas in adults,” The New England Journal of Medicine, vol. 359, no. 5, pp. 492–507, 2008.
- J. N. Sarkaria, G. J. Kitange, C. D. James et al., “Mechanisms of chemoresistance to alkylating agents in malignant glioma,” Clinical Cancer Research, vol. 14, no. 10, pp. 2900–2908, 2008.
- P. E. Thorpe, “Vascular targeting agents as cancer therapeutics,” Clinical Cancer Research, vol. 10, no. 2, pp. 415–427, 2004.
- G. M. Tozer, S. M. Ameer-Beg, J. Baker et al., “Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy,” Advanced Drug Delivery Reviews, vol. 57, no. 1, pp. 135–152, 2005.
- M. A. Konerding, W. Malkusch, B. Klapthor et al., “Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts,” British Journal of Cancer, vol. 80, no. 5-6, pp. 724–732, 1999.
- R. J. Gillies, P. A. Schornack, T. W. Secomb, and N. Raghunand, “Causes and effects of heterogeneous perfusion in tumors,” Neoplasia, vol. 1, no. 3, pp. 197–207, 1999.
- A. Eberhard, S. Kahlert, V. Goede, B. Hemmerlein, K. H. Plate, and H. G. Augustin, “Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies,” Cancer Research, vol. 60, no. 5, pp. 1388–1393, 2000.
- H. Hashizume, P. Baluk, S. Morikawa et al., “Openings between defective endothelial cells explain tumor vessel leakiness,” The American Journal of Pathology, vol. 156, no. 4, pp. 1363–1380, 2000.
- J. Tu, M. A. Stoodley, M. K. Morgan, and K. P. Storer, “Ultrastructure of perinidal capillaries in cerebral arteriovenous malformations,” Neurosurgery, vol. 58, no. 5, pp. 961–969, 2006.
- J. He, Y. Yin, T. A. Luster, L. Watkins, and P. E. Thorpe, “Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma,” Clinical Cancer Research, vol. 15, no. 22, pp. 6871–6880, 2009.
- J. He, T. A. Luster, and P. E. Thorpe, “Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids,” Clinical Cancer Research, vol. 13, no. 17, pp. 5211–5218, 2007.
- X. Huang, M. Bennett, and P. E. Thorpe, “A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice,” Cancer Research, vol. 65, no. 10, pp. 4408–4416, 2005.
- S. Ran, A. Downes, and P. E. Thorpe, “Increased exposure of anionic phospholipids on the surface of tumor blood vessels,” Cancer Research, vol. 62, no. 21, pp. 6132–6140, 2002.
- S. Ran, J. He, X. Huang, M. Soares, D. Scothorn, and P. E. Thorpe, “Anti-tumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in mice,” Clinical Cancer Research, vol. 11, no. 4, pp. 1551–1562, 2005.
- M. Jennewein, M. A. Lewis, D. Zhao et al., “Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine,” Clinical Cancer Research, vol. 14, no. 5, pp. 1377–1385, 2008.
- K. Storer, J. Tu, A. Karunanayaka et al., “Coadministration of low-dose lipopolysaccharide and soluble tissue factor induces thrombosis after radiosurgery in an animal arteriovenous malformation model,” Neurosurgery, vol. 61, no. 3, pp. 604–611, 2007.
- V. Sammons, A. Davidson, J. Tu, and M. A. Stoodley, “Endothelial cells in the context of brain arteriovenous malformations,” Journal of Clinical Neuroscience, vol. 18, no. 2, pp. 165–170, 2011.
- K. P. Storer, J. Tu, A. Karunanayaka, M. K. Morgan, and M. A. Stoodley, “Thrombotic molecule expression in cerebral vascular malformations,” Journal of Clinical Neuroscience, vol. 14, no. 10, pp. 975–980, 2007.
- K. P. Storer, J. Tu, A. Karunanayaka, M. K. Morgan, and M. A. Stoodley, “Inflammatory molecule expression in cerebral arteriovenous malformations,” Journal of Clinical Neuroscience, vol. 15, no. 2, pp. 179–184, 2008.
- A. Karunanyaka, J. Tu, A. Watling, K. P. Storer, A. Windsor, and M. A. Stoodley, “Endothelial molecular changes in a rodent model of arteriovenous malformation: laboratory investigation,” Journal of Neurosurgery, vol. 109, no. 6, pp. 1165–1172, 2008.
- K. P. Storer, A. Karunanayaka, J. Tu, R. Smee, A. Watling, and M. A. Stoodley, “Identification of potential molecular targets for directed thrombosis after radiosurgery in an animal arteriovenous malformation model,” Neurosurgery, vol. 58, no. 2, pp. 403–404, 2006.
- J. Tu, M. A. Stoodley, M. K. Morgan, and K. P. Storer, “Responses of arteriovenous malformations to radiosurgery: ultrastructural changes,” Neurosurgery, vol. 58, no. 4, pp. 749–758, 2006.
- S. Liu, V. Sammons, J. Fairhall, et al., “Molecular responses of brain endothelial cells to radiation,” Journal of Clinical Neuroscience, vol. 19, no. 8, pp. 1154–1158, 2012.
- Z. Hu, Y. Xing, Y. Qian, et al., “Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist,” Journal of Radiation Research, vol. 54, no. 2, pp. 243–250, 2013.
- E. W. Newcomb and D. Zagzag, “The murine GL261 glioma experimental model to assess novel brain tumor treatment,” in CNS Cancer, Cancer Drug Discovery and Development, E. G. van Meir, Ed., vol. 1, pp. 227–241, 2009.
- National Health and Medical Research Council, Australian Code of Practice for the Care and Use of Animals for Scientific Purposes, 7th edition, 2004.
- J. L. Hintze, “Analysis of variance,” in Number Cruncher Statistical Systems (NCSS) 97-User’s Guide-I, pp. 205–278, J. L. Hintze, Kaysville, Utah, USA, 1997.
- N. E. A. Crompton, “Telomeres, senescence and cellular radiation response,” Cellular and Molecular Life Sciences, vol. 53, no. 7, pp. 568–575, 1997.
- E. Cohen-Jonathan, E. J. Bernhard, and W. G. McKenna, “How does radiation kill cells?” Current Opinion in Chemical Biology, vol. 3, no. 1, pp. 77–83, 1999.
- M. F. Milosevic, A. W. Fyles, and R. P. Hill, “The relationship between elevated interstitial fluid pressure and blood flow in tumors: a bioengineering analysis,” International Journal of Radiation Oncology Biology Physics, vol. 43, no. 5, pp. 1111–1123, 1999.
- L. F. Fajardo and M. Berthrong, “Vascular lesions following radiation,” Pathology Annual, vol. 23, part 1, pp. 297–330, 1988.
- G. S. Dimitrievich, K. Fischer-Dzoga, and M. L. Griem, “Radiosensitivity of vascular tissue. I. Differential radiosensitivity of capillaries: a quantitative in vivo study,” Radiation Research, vol. 99, no. 3, pp. 511–535, 1984.
- L. F. Fajardo, “Is the pathology of radiation injury different in small vs large blood vessels?” Cardiovascular Radiation Medicine, vol. 1, no. 1, pp. 108–110, 1999.
- T. Kamiryo, M. B. S. Lopes, N. F. Kassell, L. Steiner, and K. S. Lee, “Radiosurgery-induced microvascular alterations precede necrosis of the brain neuropil,” Neurosurgery, vol. 49, no. 2, pp. 409–415, 2001.
- M. M. O'Connor and M. R. Mayberg, “Effects of radiation on cerebral vasculature: a review,” Neurosurgery, vol. 46, no. 1, pp. 138–151, 2000.
- F. Paris, Z. Fuks, A. Kang et al., “Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice,” Science, vol. 293, no. 5528, pp. 293–297, 2001.
- B. C. Baguley, “Antivascular therapy of cancer: DMXAA,” The Lancet Oncology, vol. 4, no. 3, pp. 141–148, 2003.
- X. Huang, G. Molema, S. King, L. Watkins, T. S. Edgington, and P. E. Thorpe, “Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature,” Science, vol. 275, no. 5299, pp. 547–550, 1997.
- H. H. Sedlacek, “Pharmacological aspects of targeting cancer gene therapy to endothelial cells,” Critical Reviews in Oncology/Hematology, vol. 37, no. 3, pp. 169–215, 2001.
- P. E. Thorpe, D. J. Chaplin, and D. C. Blakey, “The first international conference on vascular targeting: meeting overview,” Cancer Research, vol. 63, no. 5, pp. 1144–1147, 2003.
- R. A. Brekken and P. E. Thorpe, “Vascular endothelial growth factor and vascular targeting of solid tumors,” Anticancer Research, vol. 21, no. 6, pp. 4221–4229, 2001.
- C. Carpenito, P. D. Davis, S. T. Dougherty, and G. J. Dougherty, “Exploiting the differential production of angiogenic factors within the tumor microenvironment in the design of a novel vascular-targeted gene therapy-based approach to the treatment of cancer,” International Journal of Radiation Oncology Biology Physics, vol. 54, no. 5, pp. 1473–1478, 2002.
- R. B. Pedley, E. El-Emir, A. A. Flynn et al., “Synergy between vascular targeting agents and antibody-directed therapy,” International Journal of Radiation Oncology Biology Physics, vol. 54, no. 5, pp. 1524–1531, 2002.
- P. Wachsberger, R. Burd, and A. P. Dicker, “Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction,” Clinical Cancer Research, vol. 9, no. 6, pp. 1957–1971, 2003.
- A. Marconescu and P. E. Thorpe, “Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells,” Biochimica et Biophysica Acta, vol. 1778, no. 10, pp. 2217–2224, 2008.
- S. Ran and P. E. Thorpe, “Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy,” International Journal of Radiation Oncology Biology Physics, vol. 54, no. 5, pp. 1479–1484, 2002.
- K. Balasubramanian and A. J. Schroit, “Aminophospholipid asymmetry: a matter of life and death,” Annual Review of Physiology, vol. 65, pp. 701–734, 2003.
- A. Kuin, F. Citarella, Y. G. Oussoren, A. F. van der Wal, L. G. H. Dewit, and F. A. Stewart, “Increased glomerular Vwf after kidney irradiation is not due to increased biosynthesis or endothelial cell proliferation,” Radiation Research, vol. 156, no. 1, pp. 20–27, 2001.
- M. Verheij, L. G. H. Dewit, M. N. Boomgaard, H.-J. M. Brinkman, and J. A. van Mourik, “Ionizing radiation enhances platelet adhesion to the extracellular matrix of human endothelial cells by an increase in the release of von Willebrand factor,” Radiation Research, vol. 137, no. 2, pp. 202–207, 1994.
- B. Fadeel and D. Xue, “The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease,” Critical Reviews in Biochemistry and Molecular Biology, vol. 44, no. 5, pp. 264–277, 2009.
- J. H. Jandl, Blood: Textbook of Hematology, Little, Brown and Company, Boston, Mass, USA, 1st edition, 1996.
- Y. Ebisawa, T. Kono, M. Yoneda et al., “Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats,” Journal of Surgical Research, vol. 118, no. 2, pp. 183–189, 2004.
- J. Gao, B. X. Zeng, L. J. Zhou, and S. Y. Yuan, “Protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats,” British Journal of Anaesthesia, vol. 92, no. 2, pp. 277–279, 2004.
- J. C. Meltzer, B. J. MacNeil, V. Sanders et al., “Contribution of the adrenal glands and splenic nerve to LPS-induced splenic cytokine production in the rat,” Brain, Behavior, and Immunity, vol. 17, no. 6, pp. 482–497, 2003.
- J. Philipp, A. Dienst, M. Unruh et al., “Soluble tissue factor induces coagulation on tumor endothelial cells in vivo if coadministered with low-dose lipopolysaccharides,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 5, pp. 905–910, 2003.