What Would Be the Most Appropriate 𝜶/𝜷 Ratio in the Setting of Stereotactic Body Radiation Therapy for Early Stage Non-Small Cell Lung Cancer

Table 1

Local tumor control following SBRT for early stage NSCLC.

References	No. of fractions	No. of patients/no. of total patients	Fractional dose (isocenter, Gy)	Median followup (months)	Local control	Dose calculation algorithm
Kopek et al. [17]	3	62/88	15.0	44.0	93.1%	PB^¶
Koto et al. [22]		20/31	15.0	32.0	75.0%	Batho^¶
Hoyer et al. [24]		40/40	15.0	29.0	92.5%	NSS^¶
Bral et al. [35]		23/40	18.0	16.0	91.3%	NSS, BrainLab^¶
Ricardi et al. [26]		62/62	18.8	28.0	93.6%	CC^¶
Guckenberger et al. [37]		32/124	19.2	14.0	100.0%	CC^¶
Ng et al. [30]		12/20	20.0	21.0	83.3%	NSS, BrainLab^¶
Andratschke et al. [31]		92/92	20.8*	21.0	89.1%	NSS^¶
Nyman et al. [18]		45/45	21.0	43.0	80.0%	Batho^¶
Vahdat et al. [19]		20/20	21.3*	43.0	95.0%	NSS, Cyberknife^¶
Crabtree et al. [33]		76/76	21.8	19.0	93.4%	NSS, Triology^¶
Baumann et al. [20]		57/57	22.0	35.0	93.0%	PB^¶
Timmerman et al. [21]		59/59	22.5	34.4	98.2%	NSS^¶
Turzer et al. [38]		31/36	22.9	13.8	100.0%	CC^¶
Fakiris et al. [16]		34/70	25.0	50.2	97.1%	NSS^¶
van der Voort van Zyp et al. [36]		59/70	25.8	15.0	96.6%	NSS, Cyberknife^¶
Matsuo et al. [23]	4	101/101	12	31.4	86.1%	PB
Baba et al. [28]		85/124	12	26.0	87.1%	NSS
Stephans et al. [32]	5	56/86	10.2	19.8	96.4%	NSS, BrainLab^¶
Takeda et al. [29]		63/63	12.5	24.0	95.6%	SC
Lagerwaard et al. [25]		>100^‡/—	15.0	29.0	95.7%	NSS, BrainLab^¶
Onimaru et al. [34]	8 to 10	17/45	6.0	18.0	70.6%	PB & SC^¶
Onishi et al. [39]		35/35	7.3	13.0	94.3%	NSS^¶
Xia et al. [27]		43/43	10.0	27.0	96.0%	NSS, Gamma knife

 *Median or mean dose; ^‡Personal communication with Dr. Lagerwaard. ¶Image guidance applied. CC: Collapsed cone; NSS: not specifically stated; PB: pencil beam; S: superposition.