17β-Estradiol Attenuates Poststroke Depression and Increases Neurogenesis in Female Ovariectomized Rats

Figure 2

E₂ administration after ischemic stroke reverses depressive-like behavior (𝑛=10). (a) E₂-treated animals showed increased percentage of sucrose consumption at 1 week and 2 weeks after E₂ administration, compared to vehicle-treated animals. (b) E₂-treated animals showed no significant differences to vehicle-treated on climbing ability. E₂-treated rats showed increased swimming behavior (c) and decreased immobility (d) after focal ischemia, compared to vehicle-treated ischemic animals. Data were presented as mean ± SEM. ^∗𝑃<0.05, ^∗∗𝑃<0.001.

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