Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans
Table 2
Frequency of AMACR (5p13) polymorphisms and association with prostate cancer risk.
SNP
Genotype
Cases (%)
Controls (%)
Crude OR (95 %CI)
P
Adjusted OR (95 %CI)a
P
rs2278008
A/A
145 (74.7)
109 (64.9)
Ref.
Ref.
0.0407
A/G
47 (24.2)
56 (33.3)
0.63 (0.40–1.00)
0.0500
0.51 (0.29–0.91)
0.0220
G/G
2 (1.0)
3 (1.8)
0.50 (0.08–3.05)
0.4535
0.42 (0.06–2.99)
0.3892
A/G + G/G
49 (25.3)
59 (35.1)
0.62 (0.40–0.98)
0.0415
0.51 (0.29–0.89)
0.0178
A allele
337 (86.9)
274 (81.5)
Ref.
Ref.
G allele
51 (13.1)
62 (18.5)
0.67 (0.45–1.00)
0.0506
0.57 (0.35–0.93)
0.0251
rs34677
G/G
143 (73.7)
123 (73.2)
Ref.
Ref.
0.8638
G/T
46 (23.7)
43 (25.6)
0.92 (0.57–1.49)
0.7343
1.27 (0.66–2.42)
0.4761
T/T
5 (2.6)
2 (1.2)
2.15 (0.41–11.27)
0.3656
1.81 (0.25–12.93)
0.5559
G/T + T/T
51 (26.3)
45 (26.8)
0.97 (0.61–1.56)
0.9149
1.30 (0.70–2.44)
0.4069
G allele
332 (85.6)
289 (86.0)
Ref.
Ref.
T allele
56 (14.4)
47 (14.0)
1.04 (0.68–1.58)
0.8644
1.30 (0.74–2.27)
0.3656
rs2287939
C/C
149 (76.8)
124 (73.8)
Ref.
Ref.
0.7474
C/T
39 (20.1)
41 (24.4)
0.79 (0.48–1.30)
0.3587
0.66 (0.36–1.23)
0.1935
T/T
6 (3.1)
3 (1.8)
1.66 (0.41–6.79)
0.4777
0.78 (0.14–4.21)
0.7681
C/T + T/T
45 (23.2)
44 (26.2)
0.85 (0.53–1.37)
0.5095
0.67 (0.37–1.22)
0.1938
C allele
337 (86.9)
289 (86.0)
Ref.
Ref.
T allele
51 (13.1)
47 (14.0)
0.93 (0.61–1.43)
0.7403
0.72 (0.43–1.22)
0.2268
rs10941112
G/G
69 (35.6)
76 (45.2)
Ref.
Ref.
0.2155
G/A
96 (49.5)
66 (39.3)
1.60 (1.02–2.52)
0.0410
1.52 (0.86–2.70)
0.1514
A/A
29 (14.9)
26 (15.5)
1.23 (0.66–2.29)
0.5164
1.24 (0.56–2.76)
0.5979
G/A + A/A
125 (64.4)
92 (54.8)
1.50 (0.98–2.28)
0.0616
1.44 (0.85–2.47)
0.1779
G allele
234 (60.3)
218 (64.9)
Ref.
Ref.
A allele
154 (39.7)
118 (35.1)
1.22 (0.90–1.65)
0.2055
1.21 (0.82–1.79)
0.3273
rs3195676
G/G
69 (35.9)
74 (44.0)
Ref.
Ref.
0.2955
G/A
94 (49.0)
68 (40.5)
1.48 (0.94–2.33)
0.0883
1.40 (0.79–2.48)
0.2553
A/A
29 (15.1)
26 (15.5)
1.20 (0.64–2.23)
0.5728
1.19 (0.53–2.66)
0.6729
G/A + A/A
123 (64.1)
94 (56.0)
1.40 (0.92–2.14)
0.1172
1.34 (0.78–2.29)
0.2849
G allele
232 (60.4)
216 (64.3)
Ref.
Ref.
A allele
152 (39.6)
120 (35.7)
1.18 (0.87–1.60)
0.2856
1.16 (0.79–1.72)
0.4404
SNP: single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval; AMACR: (R)-alpha-methyl-CoA racemase. Adjusted for age, smoking quantity, alcohol drinking, and family history of prostate cancer. Cochran-Armitage trend test for the number of variant alleles.
