Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans
Table 4
Association analysis of AMACR (5p13) polymorphisms with AMACR expressing prostate cancer risk.
SNP
Genotype
Cases (%)
Controls (%)
Crude OR (95%CI)
P
Adjusted OR (95%CI)a
P
rs2278008
A/A
120 (77.9)
109 (64.9)
Ref.
Ref.
0.0088
A/G
33 (21.4)
56 (33.3)
0.54 (0.32–0.88)
0.0147
0.48 (0.26–0.89)
0.0207
G/G
1 (0.6)
3 (1.8)
0.30 (0.03–2.95)
0.3040
0.37 (0.04–3.92)
0.4091
A/G + G/G
34 (22.1)
59 (35.1)
0.52 (0.32–0.86)
0.0104
0.47 (0.26–0.87)
0.0167
A allele
246 (87.9)
274 (81.5)
Ref.
Ref.
G allele
34 (12.1)
62 (18.5)
0.61 (0.39 –0.96)
0.0327
0.59 (0.34–1.02)
0.0598
rs34677
G/G
113 (73.4)
123 (73.2)
Ref.
Ref.
0.7336
G/T
36 (23.4)
43 (25.6)
0.91 (0.55 –1.52)
0.7217
1.33 (0.66–2.67)
0.4217
T/T
5 (3.2)
2 (1.2)
2.72 (0.52–14.29)
0.2373
2.28 (0.29–8.15)
0.4354
G/T + T/T
41 (26.6)
45 (26.8)
0.99 (0.60–1.63)
0.9738
1.40 (0.71–2.73)
0.3300
G allele
239 (85.4)
289 (86.0)
Ref.
Ref.
T allele
41 (14.6)
47 (14.0)
1.05 (0.67–1.66)
0.8169
1.35 (0.72–2.50)
0.3479
rs2287939
C/C
122 (79.2)
124 (73.8)
Ref.
Ref.
0.2589
C/T
30 (19.5)
41 (24.4)
0.74 (0.44–1.27)
0.2763
0.72 (0.37–1.38)
0.3207
T/T
2 (1.3)
3 (1.8)
0.68 (0.11–4.13)
0.6728
0.50 (0.05–4.88)
0.5550
C/T + T/T
32 (20.8)
44 (26.2)
0.74 (0.44–1.24)
0.2542
0.70 (0.37–1.33)
0.2775
C allele
247 (88.2)
289 (86.0)
Ref.
Ref.
T allele
33 (11.8)
47 (14.0)
0.82 (0.51–1.32)
0.4186
0.79 (0.44–1.42)
0.4274
rs10941112
G/G
58 (37.7)
76 (45.2)
Ref.
Ref.
0.4154
G/A
74 (48.1)
66 (39.3)
1.47 (0.91–2.37)
0.1134
1.45 (0.79–2.66)
0.2322
A/A
22 (14.3)
26 (15.5)
1.11 (0.57–2.15)
0.7601
1.08 (0.45–2.57)
0.8655
G/A + A/A
96 (62.3)
92 (54.8)
1.37 (0.88–2.13)
0.1688
1.35 (0.76–2.38)
0.3041
G allele
107 (38.2)
118 (35.1)
Ref.
Ref.
A allele
173 (61.8)
218 (64.9)
1.14 (0.82–1.59)
0.4271
1.12 (0.73–1.71)
0.6157
rs3195676
G/G
58 (37.9)
74 (44.0)
Ref.
Ref.
0.5202
G/A
73 (47.7)
68 (40.5)
1.37 (0.85–2.21)
0.1959
1.34 (0.73–2.46)
0.3503
A/A
22 (14.4)
26 (15.5)
1.08 (0.56–2.10)
0.8211
1.03 (0.43–2.46)
0.9503
G/A + A/A
95 (62.1)
94 (56.0)
1.29 (0.82–2.02)
0.2646
1.25 (0.71–2.22)
0.4360
G allele
106 (38.1)
120 (35.7)
Ref.
Ref.
A allele
172 (61.9)
216 (64.3)
1.11 (0.80–1.54)
0.5364
1.07 (0.70–1.64)
0.7577
SNP: single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval. Adjusted for age, smoking quantity, alcohol drinking, and family history of prostate cancer. Cochran-Armitage trend test for the number of variant alleles.
