Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans
Table 5
Association between AMACR (5p13) polymorphisms and prognostic factors in prostate cancer patients in AMACR expressing subgroup.
rs2278008
AG + GG (%)
AA (%)
OR (95% CI)
P
Adjusted OR (95% CI)a
P
G (%)
A (%)
OR (95% CI)
P
Adjusted OR (95% CI)a
P
Gleason score
<7
23 (67.6)
59 (49.2)
22 (64.7)
130 (52.8)
≥7
11 (32.4)
61 (50.8)
0.46 (0.21–1.03)
0.0598
0.43 (0.19–0.99)
0.0482
12 (35.3)
116 (47.2)
0.61 (0.29–1.29)
0.1963
0.59 (0.28–1.28)
0.1823
pTstage
≤pT2b
7 (20.6)
28 (23.3)
7 (20.6)
53 (21.5)
≥pT2c
27 (79.4)
92 (76.7)
1.17 (0.46–2.98)
0.7362
1.24 (0.48–3.18)
0.6530
27 (79.4)
193 (78.5)
1.06 (0.44–2.57)
0.8986
1.12 (0.46–2.74)
0.7986
rs34677
GT + TT (%)
GG (%)
T (%)
G (%)
Gleason score
<7
21 (51.2)
61 (54.0)
21 (51.2)
131 (54.8)
≥7
20 (48.8)
52 (46.0)
1.12 (0.55–2.28)
0.7614
1.20 (0.57–2.53)
0.6249
20 (48.8)
108 (45.2)
1.16 (0.60–2.24)
0.6698
1.22 (0.61–2.42)
0.5751
pTstage
≤pT2b
15 (36.6)
20 (17.7)
14 (34.1)
46 (19.2)
≥pT2c
26 (63.4)
93 (82.3)
0.37 (0.17–0.83)
0.0154
0.35 (0.15–0.79)
0.0119
27 (65.9)
193 (80.8)
0.46 (0.22–0.95)
0.0346
0.43 (0.21–0.91)
0.0281
rs2287939
CT + TT (%)
CC (%)
T (%)
C (%)
Gleason score
<7
19 (59.4)
63 (51.6)
19 (57.6)
133 (53.8)
≥7
13 (40.6)
59 (48.4)
0.73 (0.33–1.61)
0.4360
0.62 (0.27–1.44)
0.2697
14 (42.4)
114 (46.2)
0.86 (0.41–1.79)
0.6865
0.76 (0.35–1.64)
0.4819
pTstage
≤pT2b
7 (21.9)
28 (23.0)
7 (21.2)
53 (21.5)
≥pT2c
25 (78.1)
94 (77.0)
1.06 (0.42–2.72)
0.8972
1.07 (0.41–2.77)
0.8944
26 (78.8)
194 (78.5)
1.01 (0.42–2.47)
0.9743
1.02 (0.41–2.50)
0.9722
rs10941112
GA + AA (%)
GG (%)
A (%)
G (%)
Gleason score
<7
46 (47.9)
36 (62.1)
55 (51.4)
97 (56.1)
≥7
50 (52.1)
22 (37.9)
1.78 (0.92–3.46)
0.0895
1.73 (0.87–3.45)
0.1165
52 (48.6)
76 (43.9)
1.21 (0.74–1.96)
0.4464
1.18 (0.72–1.93)
0.5217
pTstage
≤pT2b
15 (15.6)
20 (34.5)
15 (14.0)
45 (26.0)
≥pT2c
81 (84.4)
38 (65.5)
2.84 (1.31–6.15)
0.0080
2.97 (1.35–6.52)
0.0066
92 (86.0)
128 (74.0)
2.16 (1.13–4.10)
0.0191
2.23 (1.17–4.27)
0.0153
rs3195676
GA + AA (%)
GG (%)
A (%)
G (%)
Gleason score
<7
46 (48.4)
36 (62.1)
55 (51.9)
97 (56.4)
≥7
49 (51.6)
22 (37.9)
1.74 (0.90–3.39)
0.1019
1.71 (0.86–3.40)
0.1289
51 (48.1)
75 (43.6)
1.20 (0.74–1.95)
0.4635
1.17 (0.71–1.93)
0.5294
pTstage
≤pT2b
15 (15.8)
20 (34.5)
15 (14.2)
45 (26.2)
≥pT2c
80 (84.2)
38 (65.5)
2.81 (1.30–6.08)
0.0089
2.94 (1.34–6.45)
0.0071
91 (85.8)
127 (73.8)
2.15 (1.13–4.09)
0.0197
2.23 (1.16–4.27)
0.0155
pTstage: pathologic stage; OR: odds ratio; 95% CI: 95% confidence interval. Adjusted for age, smoking quantity, alcohol drinking, and family history of prostate cancer.
