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BioMed Research International
Volume 2013 (2013), Article ID 394316, 9 pages
http://dx.doi.org/10.1155/2013/394316
Review Article

Interleukin-13 +1923C/T Polymorphism Is Associated with Asthma Risk: A Meta-Analysis

1Department of Intensive Care Medicine, No. 411 Hospital of PLA, Shanghai 200080, China
2Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
3Department of Respiratory Disease, Fuzhou Military General Hospital, Fuzhou, Fujian 350025, China

Received 12 March 2013; Accepted 22 May 2013

Academic Editor: Koji Kawakami

Copyright © 2013 Yongan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. We performed this study to assess the association by the method of meta-analysis. A systematic search current to October 16, 2012, was conducted using PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) and identified ten studies comprising 13698 cases and 38209 controls. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. There was a significant association between IL-13 +1923C/T polymorphism and asthma risk in codominant model. When stratified by ethnicity, IL-13 +1923C/T polymorphism remained significantly associated with higher asthma risk in Asians and Caucasians. In the subgroup analysis by study quality, a significantly increased asthma risk was observed in high quality studies. Sensitivity analysis and cumulative analysis further strengthened the validity of the results. No publication bias was found in this meta-analysis. In conclusion, results from this meta-analysis suggested that IL-13 +1923C/T polymorphism was a risk factor of asthma.