Interleukin-13 +1923C/T Polymorphism Is Associated with Asthma Risk: A Meta-Analysis

Table 3

Determination of the genetic effect of IL-13 +1923C/T on asthma and subgroup analyses.

Comparison	Study	Sample size		Number of studies	Test of association			Model	Heterogeneity
		Case	Control		OR (95% CI)	𝑍	𝑃 value		𝜒^2	𝑃 value	𝐼^2 (%)
TT versus CC	Overall	8758	24034	12	1.47 (1.25–1.73)	4.60	<0.00001	R	15.51	0.26	29.0
TC versus CC	Overall	12735	35447	12	1.21 (1.10–1.33)	4.03	<0.0001	R	15.48	0.16	29.0
TT versus TC	Overall	5897	16889	12	1.14 (1.04–1.25)	2.69	0.007	R	8.81	0.64	0.0
TT versus CC	Asian	820	10855	5	1.67 (1.20–2.34)	3.02	0.003	R	7.29	0.12	45.0
TT versus CC	Caucasian	7690	12978	5	1.45 (1.11–1.88)	2.75	0.006	R	5.97	0.20	33.0
TT versus CC	High quality	8575	23839	10	1.33 (1.21–1.47)	5.69	<0.00001	R	7.64	0.57	0.0
TC versus CC	Asian	1334	16948	5	1.27 (1.05–1.55)	2.46	0.01	R	6.15	0.19	35.0
TC versus CC	Caucasian	11134	18301	5	1.17 (1.05–1.30)	2.89	0.004	R	5.44	0.24	27.0
TC versus CC	High quality	12436	35146	10	1.15 (1.09–1.22)	5.13	<0.00001	R	9.28	0.41	3.0

R: random-effects model.