- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 396272, 10 pages
Molecular and Survival Differences between Familial and Sporadic Gastric Cancers
1Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, 201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan
2Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
3Division of Colorectal Surgery, Department of Surgery, Taipei Veterans General Hospital, 201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan
4National Yang-Ming University, Taipei, Taiwan
5National Yang-Ming University Hospital, 152 Xin-Min Road, Yilan 26042, Taiwan
6Department of Pathology, Taipei Veterans General Hospital, 201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan
7Department of Medical Research and Education, Taipei Veterans General Hospital, 201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan
8Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
Received 11 October 2012; Revised 27 December 2012; Accepted 24 January 2013
Academic Editor: Ozgur Cogulu
Copyright © 2013 Wen-Liang Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. M. Parkin, F. I. Bray, and S. S. Devesa, “Cancer burden in the year 2000. The global picture,” European Journal of Cancer, vol. 37, no. 8, pp. S4–S66, 2001.
- L. Ottini, M. Falchetti, R. Lupi et al., “Patterns of genomic instability in gastric cancer: clinical implications and perspectives,” Annals of Oncology, vol. 17, no. 7, pp. vii97–vii102, 2006.
- C. Oliveira, R. Seruca, M. Seixas, and M. Sobrinho-Simões, “The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different “target genes”: a study of the TGFβ RII, IGFII R, and BAX genes,” American Journal of Pathology, vol. 153, no. 4, pp. 1211–1219, 1998.
- M. Gu, D. Kim, Y. Bae, J. Choi, S. Kim, and S. Song, “Analysis of microsatellite instability, protein expression and methylation status of hMLH1 and hMSH2 genes in gastric carcinomas,” Hepato-Gastroenterology, vol. 56, no. 91-92, pp. 899–904, 2009.
- C. Pedrazzani, G. Corso, S. Velho et al., “Evidence of tumor microsatellite instability in gastric cancer with familial aggregation,” Familial Cancer, vol. 8, no. 3, pp. 215–220, 2009.
- J. Bacani, R. Zwingerman, N. Di Nicola et al., “Tumor microsatellite instability in early onset gastric cancer,” Journal of Molecular Diagnostics, vol. 7, no. 4, pp. 465–477, 2005.
- M. Leite, G. Corso, S. Sousa et al., “MSI phenotype and MMR alterations in familial and sporadic gastric cancer,” International Journal of Cancer, vol. 128, no. 7, pp. 1606–1613, 2011.
- Y. W. Ye, R. Z. Dong, Y. Zhou et al., “Prognostic analysis of familial gastric cancer in Chinese population,” Journal of Surgical Oncology, vol. 104, no. 1, pp. 76–82, 2011.
- C. Oliveira, P. Ferreira, S. Nabais et al., “E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients,” European Journal of Cancer, vol. 40, no. 12, pp. 1897–1903, 2004.
- F. M. Richards, S. A. McKee, M. H. Rajpar et al., “Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer,” Human Molecular Genetics, vol. 8, no. 4, pp. 607–610, 1999.
- I. Kluijt, E. J. Siemerink, M. G. Ausems, et al., “CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling,” International Journal of Cancer, vol. 131, no. 2, pp. 367–376, 2012.
- N. A. Ottenhof, R. F. de Wilde, F. H. Morsink, et al., “Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report,” Human Pathology, vol. 43, no. 3, pp. 457–461, 2012.
- P. Guilford, J. Hopkins, J. Harraway et al., “E-cadherin germline mutations in familial gastric cancer,” Nature, vol. 392, no. 6674, pp. 402–405, 1998.
- C. Caldas, F. Carneiro, H. T. Lynch et al., “Familial gastric cancer: overview and guidelines for management,” Journal of Medical Genetics, vol. 36, no. 12, pp. 873–880, 1999.
- M. Svrcek, “Case n(o) 6—signet ring cell intramucosal carcinoma in hereditary diffuse gastric cancer with mutated CDH1 gene,” Annales De Pathologie, vol. 31, no. 5, pp. 381–384, 2011.
- A. R. Brooks-Wilson, P. Kaurah, G. Suriano et al., “Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria,” Journal of Medical Genetics, vol. 41, no. 7, pp. 508–517, 2004.
- C. Oliveira, R. Seruca, and F. Carneiro, “Hereditary gastric cancer,” Best Practice and Research, vol. 23, no. 2, pp. 147–157, 2009.
- Z. H. Ma, Q. Z. Ren, Y. F. Zhao, et al., “Comparison of clinicopathological features and prognosis in familial and sporadic gastric cancer,” Zhonghua Wei Chang Wai Ke Za Zhi, vol. 14, no. 10, pp. 793–795, 2011.
- L. Ottini, D. Palli, M. Falchetti et al., “Microsatellite instability in gastric cancer is associated with tumor location and family history in a high-risk population from Tuscany,” Cancer Research, vol. 57, no. 20, pp. 4523–4529, 1997.
- K. Shinmura, W. Yin, J. Isogaki et al., “Stage-dependent evaluation of microsatellite instability in gastric carcinoma with familial clustering,” Cancer Epidemiology Biomarkers and Prevention, vol. 6, no. 9, pp. 693–697, 1997.
- G. Keller, M. Rudelius, H. Vogelsang et al., “Microsatellite instability and loss of heterozygosity in gastric carcinoma in comparison to family history,” American Journal of Pathology, vol. 152, no. 5, pp. 1281–1289, 1998.
- K. Kanemitsu, K. Kawasaki, M. Nakamura et al., “MSI is frequently recognized among gastric cancer patients with a family history of cancer,” Hepato-Gastroenterology, vol. 54, no. 80, pp. 2410–2414, 2007.
- Y. Yanagisawa, Y. Akiyama, S. Iida, et al., “Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability,” International Journal of Cancer, vol. 85, no. 1, pp. 50–53, 2000.
- J. M. Chong, M. Fukayama, Y. Hayashi et al., “Microsatellite instability in the progression of gastric carcinoma,” Cancer Research, vol. 54, no. 17, pp. 4595–4597, 1994.
- “TNM classification of malignant tumours,” in International Union AgaInst Cancer (UICC), L. H. Sobin and C. Wittekind, Eds., Wiley, New York, NY, USA, 7th edition, 2009.
- C. R. Boland, S. N. Thibodeau, S. R. Hamilton et al., “A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer,” Cancer Research, vol. 58, no. 22, pp. 5248–5257, 1998.
- S. C. Chang, J. K. Lin, S. H. Yang, H. S. Wang, A. F. Y. Li, and C. W. Chi, “Relationship between genetic alterations and prognosis in sporadic colorectal cancer,” International Journal of Cancer, vol. 118, no. 7, pp. 1721–1727, 2006.
- J. G. Herman, J. R. Graff, S. Myöhänen, B. D. Nelkin, and S. B. Baylin, “Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 18, pp. 9821–9826, 1996.
- W. M. Grady, A. Rajput, J. D. Lutterbaugh, and S. D. Markowitz, “Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer,” Cancer Research, vol. 61, no. 3, pp. 900–902, 2001.
- L. A. Aaltonen, R. Salovaara, P. Kristo et al., “Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease,” The New England Journal of Medicine, vol. 338, no. 21, pp. 1481–1487, 1998.
- R. B. Chadwick, R. E. Pyatt, T. H. Niemann et al., “Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinoma,” Journal of Medical Genetics, vol. 38, no. 7, pp. 461–466, 2001.
- R. G. Cotton and C. R. Scriver, “Proof of “disease causing” mutation,” Human Mutation, vol. 12, no. 1, pp. 1–3, 1998.
- W. S. Samowitz, K. Curtin, H. H. Lin et al., “The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer,” Gastroenterology, vol. 121, no. 4, pp. 830–838, 2001.
- P. S. Kao, J. K. Lin, H. S. Wang et al., “The impact of family history on the outcome of patients with colorectal cancer in a veterans' hospital,” International Journal of Colorectal Disease, vol. 24, no. 11, pp. 1249–1254, 2009.
- W. L. Fang, S. C. Chang, Y. T. Lan, et al., “Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery,” World Journal of Surgery, vol. 36, no. 9, pp. 2131–2138, 2012.
- S. Beghelli, G. de Manzoni, S. Barbi et al., “Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers,” Surgery, vol. 139, no. 3, pp. 347–356, 2006.
- G. Corso, C. Pedrazzani, D. Marrelli, V. Pascale, E. Pinto, and F. Roviello, “Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma,” Archives of Surgery, vol. 144, no. 8, pp. 722–727, 2009.
- J. Y. An, H. Kim, J. H. Cheong, et al., “Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after R0 resection,” International Journal of Cancer, vol. 131, no. 2, pp. 505–511, 2012.
- S. H. Lee, J. W. Lee, Y. H. Soung et al., “BRAF and KRAS mutations in stomach cancer,” Oncogene, vol. 22, no. 44, pp. 6942–6945, 2003.
- A. A. Komar, “Genetics. SNPs, silent but not invisible,” Science, vol. 315, no. 5811, pp. 466–467, 2007.
- Y. Chen, K. Kingham, J. M. Ford, et al., “A prospective study of total gastrectomy for CDH1-positive hereditary diffuse gastric cancer,” Annals of Surgical Oncology, vol. 18, no. 9, pp. 2594–2598, 2011.