Table 1: Comparison of clinicopathological characteristics between diffuse type GC cases of sporadic and familial GCs.

Sporadic GCFamilial GC
( )( ) value
(%) (%)

Age (years) <0.001
Gender (M/F)77/3012/130.032
Tumor maximal size (cm) <0.001
Gross appearance
 Well-defined16 (15)12 (48)
 Ill-defined91 (85)13 (52)0.001
Lymphovascular invasion
 Absent/present10/9711/14<0.001
Stromal reaction type
 Medullary18 (16.8)7 (28)
 Intermediate36 (33.6)7 (28)
 Scirrhous53 (49.5)11 (44)0.435
Pathological T category
 T1/T2/T3/T44/6/26/719/2/1/13<0.001
Pathological N category
 N0/N1/N2/N315/15/17/609/2/4/100.074
Pathological TNM stage
 Stage I5 (4.7)9 (36)
 Stage II11 (10.3)2 (8)
 Stage III46 (43)7 (28)
 Stage IV45 (42)7 (28)<0.001
MSI status
 MSI-L/S100 (93.5)18 (72)
 MSI-H7 (6.5)7 (28)0.005
IHC stain for MMR protein
 Normal105 (98.1)22 (88)
 Abnormal2 (1.9)3 (12)0.047