Research Article
Molecular and Survival Differences between Familial and Sporadic Gastric Cancers
Table 1
Comparison of clinicopathological characteristics between diffuse type GC cases of sporadic and familial GCs.
| | | Sporadic GC | Familial GC | | | | () | () | value | | | (%) | (%) | |
| | Age (years) | | | <0.001 | | Gender (M/F) | 77/30 | 12/13 | 0.032 | | Tumor maximal size (cm) | | | <0.001 | | Gross appearance | | | | | Well-defined | 16 (15) | 12 (48) | | | Ill-defined | 91 (85) | 13 (52) | 0.001 | | Lymphovascular invasion | | | | | Absent/present | 10/97 | 11/14 | <0.001 | | Stromal reaction type | | | | | Medullary | 18 (16.8) | 7 (28) | | | Intermediate | 36 (33.6) | 7 (28) | | | Scirrhous | 53 (49.5) | 11 (44) | 0.435 | | Pathological T category | | | | | T1/T2/T3/T4 | 4/6/26/71 | 9/2/1/13 | <0.001 | | Pathological N category | | | | | N0/N1/N2/N3 | 15/15/17/60 | 9/2/4/10 | 0.074 | | Pathological TNM stage | | | | | Stage I | 5 (4.7) | 9 (36) | | | Stage II | 11 (10.3) | 2 (8) | | | Stage III | 46 (43) | 7 (28) | | | Stage IV | 45 (42) | 7 (28) | <0.001 | | MSI status | | | | | MSI-L/S | 100 (93.5) | 18 (72) | | | MSI-H | 7 (6.5) | 7 (28) | 0.005 | | IHC stain for MMR protein | | | | | Normal | 105 (98.1) | 22 (88) | | | Abnormal | 2 (1.9) | 3 (12) | 0.047 |
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