Research Article
Molecular and Survival Differences between Familial and Sporadic Gastric Cancers
Table 2
Comparison of clinicopathological characteristics between intestinal type GC cases of sporadic and familial GCs.
| | | Sporadic GC | Familial GC | | | | () | () | value | | | (%) | (%) | |
| | Age (years) | | | <0.001 | | Gender (M/F) | 124/29 | 24/17 | 0.006 | | Tumor maximal size (cm) | | | <0.001 | | Gross appearance | | | | | Well-defined | 64 (41.8) | 21 (51.2) | | | Ill-defined | 89 (58.2) | 20 (48.8) | 0.293 | | Lymphovascular invasion | | | | | Absent/present | 23/130 | 19/22 | <0.001 | | Stromal reaction type | | | | | Medullary | 16 (10.5) | 14 (34.2) | | | Intermediate | 104 (68) | 19 (46.3) | | | Scirrhous | 33 (21.5) | 8 (19.5) | 0.001 | | Pathological T category | | | | | T1/T2/T3/T4 | 15/22/36/80 | 16/2/7/16 | <0.001 | | Pathological N category | | | | | N0/N1/N2/N3 | 39/25/29/60 | 19/5/3/14 | 0.047 | | Pathological TNM stage | | | | | Stage I | 24 (15.7) | 16 (39) | | | Stage II | 33 (21.6) | 7 (17.1) | | | Stage III | 46 (30.1) | 8 (19.5) | | | Stage IV | 50 (32.7) | 10 (24.4) | 0.012 | | MSI status | | | | | MSI-L/S | 128 (83.7) | 35 (85.4) | | | MSI-H | 25 (16.3) | 6 (14.6) | 1.000 | | IHC stain for MMR protein | | | | | Normal | 143 (93.5) | 38 (92.7) | | | Abnormal | 10 (6.5) | 3 (7.3) | 1.000 |
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