Molecular and Survival Differences between Familial and Sporadic Gastric Cancers

Table 3

Univariate analysis and multivariate analysis of factors affecting overall survival of GC patients after curative surgery.

	Univariate analysis		Multivariate analysis
	OR (CI)	P value	OR (CI)	P value
Age (<65, ≥65 years)	1.52 (1.04–2.23)	0.031
Gender (male, female)	0.62 (0.42–0.93)	0.020	0.66 (0.44–0.98)	0.038
Tumor size (<5 cm, ≥5 cm)	2.15 (1.47–3.13)	<0.001
Lauren’s classification (intestinal/diffuse)	0.85 (0.60–1.20)	0.347
Lymphovascular invasion (−, +)	3.21 (1.99–5.17)	<0.001
Stromal reaction type (medullary, intermediate, and scirrhous)	1.47 (1.15–1.87)	0.002
Family history (−, +)	0.43 (0.27–0.71)	0.001
MSI status (MSI-L/S, MSI-H)	0.52 (0.28–0.96)	0.035	0.50 (0.27–0.93)	0.029
TNM stage (I, II, III)	2.43 (1.89–3.13)	<0.001	2.44 (1.89–3.14)	<0.001

OR: odds ratio, CI: confidence interval.