Table 1: Body weight, metabolic balance, and renal function in control and PAN-NS rats, seven and fourteen days after injection.

Day 7Day 14
ControlPAN-NSControlPAN-NS

Body weight (g)161 ± 2190 ± 4*241 ± 2234 ± 5
Food intake (g/24 h)14.08 ± 0.2314.85 ± 0.2915.38 ± 0.5319.29 ± 2.33
Fluid intake (mL/24 h)19.82 ± 0.8631.63 ± 1.38*21.88 ± 0.6921.86 ± 4.37
P Na+ (mmol/L)144 ± 1143 ± 1135 ± 3135 ± 1
P K+ (mmol/L)5.50 ± 0.376.13 ± 0.775.23 ± 0.255.80 ± 0.30
P creatinine (mg/L)2.84 ± 0.095.04 ± 0.39*2.20 ± 0.203.20 ± 0.30*
P proteins (g/L)47.84 ± 0.4135.98 ± 3.02*49.42 ± 1.5548.98 ± 2.98
C creatinine (mL/min)3.91 ± 0.392.25 ± 0.28*4.51 ± 1.082.24 ± 0.32*
Na+ intake (mmol/24 h)1.16 ± 0.021.20 ± 0.021.31 ± 0.051.57 ± 0.28
Ascites (g)0.61 ± 0.0814.31 ± 2.46*0.60 ± 0.101.30 ± 0.30*
Na+ balance (mmol/24 h)0.15 ± 0.060.89 ± 0.07*0.18 ± 0.13−0.61 ± 0.38*
(%)0.32 ± 0.020.05 ± 0.01*0.17 ± 0.030.53 ± 0.14*
U Na+ (mmol/24 h)1.02 ± 0.060.32 ± 0.05*1.13 ± 0.132.00 ± 0.24
U K+ (mmol/24 h)1.30 ± 0.111.82 ± 0.16*1.37 ± 0.051.92 ± 0.17*
U proteins (mg/24 h)30 ± 4298 ± 40*38 ± 7438 ± 47*
U creatinine (mmol/24 h)0.046 ± 0.0010.049 ± 0.0040.092 ± 0.0090.085 ± 0.009

Values are means ± SE; = 4 to 5 experiments per group. U: urinary; FE: fractional excretion; P: plasma; and C creatinine: creatinine clearance. * , significantly different from corresponding values in control rats.