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BioMed Research International
Volume 2013 (2013), Article ID 405743, 7 pages
http://dx.doi.org/10.1155/2013/405743
Research Article

The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

1Clinical Institute of Occupational Medicine, University Medical Centre, Ljubljana, Poljanski nasip 58, 1000 Ljubljana, Slovenia
2Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia

Received 16 April 2013; Revised 3 July 2013; Accepted 3 July 2013

Academic Editor: Surinder K. Jindal

Copyright © 2013 A. Franko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study investigated the influence of gene-gene and gene-environment interactions on the risk of developing asbestosis. The study comprised 262 cases with asbestosis and 265 controls with no asbestos-related disease previously studied for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS polymorphisms. Data on cumulative asbestos and smoking were available for all subjects. To assess gene-gene and gene-environmental interactions, logistic regression was used. The associations between MnSOD Ala −9Val polymorphism and the risk of asbestosis and between iNOS genotypes and asbestosis were modified by CAT –262 C > T polymorphism ( ). A strong interaction was found between GSTM1-null polymorphism and smoking ( ), iNOS (CCTTT)n polymorphism and smoking ( ), and between iNOS (CCTTT)n polymorphism and cumulative asbestos exposure ( ). The findings of this study suggest that the interactions between different genotypes, genotypes and smoking, and between genotypes and asbestos exposure have an important influence on the development of asbestosis and should be seriously considered in future research on occupational/environmental asbestos-related diseases.