Research Article
The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis
Table 2
The risk of asbestosis for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS genotypes*.
| |
Genotype | OR (95% CI) | | Unadjusted | Adjusted by | | Gender | Age | Smoking (ever/never) | Cumulative exposure |
| | MnSOD −9Ala/Ala versus Ala/Val + Val/Val | 1.50 (1.01–2.24) | 1.49 (1.00–2.23) | 1.46 (0.97–2.19) | 1.49 (1.00–2.23) | 1.48 (0.96–2.28) | | ECSOD Arg/Gly versus Arg/Arg | 1.63 (0.62–4.27) | 1.61 (0.61–4.22) | 1.49 (0.56–3.96) | 1.65 (0.63–4.32) | 2.07 (0.72–5.94) | | CAT −262 TT versus CT + CC | 1.36 (0.70–2.62) | 1.34 (0.70–2.60) | 1.31 (0.67–2.57) | 1.37 (0.71–2.66) | 1.91 (0.93–3.91) | | GSTM1-null versus present | 1.01 (0.71–1.43) | 1.00 (0.70–1.42) | 0.94 (0.66–1.35) | 0.99 (0.70–1.41) | 0.97 (0.67–1.42) | | GSTT1-null versus present | 0.61 (0.40–0.94) | 0.62 (0.40–0.94) | 0.63 (0.40–0.97) | 0.63 (0.41–0.97) | 0.60 (0.38–0.96) | | GSTP1 105Ile/Ile versus Ile/Val + Val/Val | 1.52 (1.08–2.15) | 1.53 (0.60–1.28) | 1.49 (1.04–2.11) | 1.54 (1.08–2.18) | 1.41 (0.97–2.05) | | GSTP1 114Ala/Ala versus Ala/Val + Val/Val | 0.97 (0.64–1.48) | 0.97 (0.64–1.48) | 0.99 (0.65–1.53) | 0.94 (0.62–1.44) | 0.86 (0.55–1.36) | | GSTP1 high versus intermediate + low conjugation capacity | 1.49 (1.06–2.10) | 1.50 (1.06–2.11) | 1.45 (1.03–1.07) | 1.50 (1.06–2.13) | 1.36 (0.94–1.98) | | iNOS LL versus SL + SS | 1.20 (0.85–1.69) | 1.20 (0.85–1.70) | 1.19 (0.84–1.69) | 1.17 (0.83–1.66) | 1.19 (0.82–1.73) |
|
|
The table summarizes the results from our previous studies.
|
