Deregulation of the miRNAs Expression in Cervical Cancer: Human Papillomavirus Implications

Table 1

MicroRNAs expression in cervical cancer.

Author	Downregulated	Upregulated	Materials and methods	Reference
Wang et al., 2008	miR-23b, miR-34a, miR-101, miR-143, miR145, miR-218, and miR-424,	miR-15a, miR146a, and miR-223	HPV16^+, HPV18^+, and HPV negative cervical cancer cell lines; cervical cancer versus age matched normal cervix samples; microarray platform, Northern blot	[11]
Li et al., 2011	Let-7b, miR-10b, miR-29a miR-99a, miR-125b, miR-126, miR-218, miR-375, and miR-424	miR-15b, miR-16, miR-17, miR-20a, miR-20b, miR-93, miR-106a, miR-155, and miR-224	Cervical fresh frozen tissues including SCC (𝑛=51), CIN2-3 (𝑛=51), and HR-HPV infected normal cervix with viral cytopathic effect (𝑛=21) and disease-free histologically normal specimens (𝑛=49); microarray platform, quantitative RT-PCR	[17]
Lui et al., 2007	let-7a-c, miR-23b, miR-143, and miR-196b	miR-21	Six cervical cancer cell lines and five normal cervical samples; cloning-based technique, Northern blot	[18]
Martinez et al., 2008	miR-126, miR-143, miR145, miR-195, miR-218, miR-368, and miR-497	miR-182, miR-183, and miR210	HPV16^+, HPV18^+, and HPV negative cervical cancer lines and cervical cancer tissue samples versus normal cervix samples; microarray platform, Northern blot, quantitative RT-PCR	[30]
Gardiner et al., 2011	miR-218 and miR-433	miR-21, miR-124, miR-135b, miR-141, miR-223, miR-301b, miR-449a, miR-449b, miR-517a, miR-517c, and miR-545	Six cervical cancer biopsies, three types of cervical dysplasia, and four normal cervical tissues; microarray platform, quantitative RT-PCR	[43]
Pereira et al., 2010	miR-26a, miR-29a miR-143, miR-145, miR-99a, miR-199a, miR-203, and miR-513	miR-10a, miR-132, miR-148a, miR196a, and miR-302b	Seven cases of high-grade SIL (CINII, 𝑛=2, and CIN III, 𝑛=5), 9 cases of low-grade SIL (CIN I), and 19 normal cervix samples; microarray platform, quantitative RT-PCR	[50]
Lee et al., 2008	miR-149 and miR203	miR9, miR127, miR-199b, miR-199s, and miR-214	Ten cervical cancer tissue samples versus ten normal cervix controls; quantitative RT-PCR	[80]