Deregulation of the miRNAs Expression in Cervical Cancer: Human Papillomavirus Implications

Table 2

miRNAs and the hallmarks of cervical cancer.

Hallmarks	Functions of miRNAs	miRNAs
Regulation of cell proliferation	Proproliferation	miR-10a, miR-15b, miR-17, miR-19a/b, miR-21, miR-34a, miR-129, miR-146a, miR-148a, miR-196, miR-210, miR-223, and miR-301b.
	Antiproliferation	let-7, miR23b, miR-26a, miR-101, miR-143, miR-145, miR-196b, 199a, miR-203, miR-424, and miR-519.
Regulation of apoptosis	Proapoptosis	miR-34a, miR-10b, miR-29a, miR-99a, and miR-195.
	Antiapoptosis	miR-17, miR-21, miR-149, miR-182, miR-203, miR-433, and miR-497.
Regulation of limitless replicative potential	Regulation of immortalization or senescence	miR-24 and miR-34a.
Regulation of angiogenesis	Proangiogenesis	let-7, miR-17, miR-20a, miR-21, miR-23b, miR-26a, miR29a, miR-126, miR133a, miR-183, miR-210, and miR-214.
	Antiangiogenesis	miR-15b, miR-16, miR-20a, miR-26a, miR-143, miR-145, miR-424, and miR497.
Regulation of immune responses	Escape from immunosurveillance	miR-155, miR-17, miR-23b, miR-26a, miR-29a, miR-17, miR-20a, miR-21, miR-93, and miR-106b.
Regulation of tumor invasion and metastasis	Prometastasis	miR-10a, miR-19a/b, miR-21, miR-23b, miR-106b, miR135, miR-155, and miR-214.
	Antimetastasis	let-7, miR-101, miR-126, miR-146a, miR-200, and miR-218.
Regulation of genomic instability	Promote genomic instability	let-7,miR-15, miR-16, miR-17, and miR20a.

Information obtained from microRNA.org-Targets and Expression. miRNAs in bold were experimentally validated in cervical cancer; underlined miRNAs were experimentally validated in other cancers.