About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 408485, 10 pages
http://dx.doi.org/10.1155/2013/408485
Research Article

Neonatal Hyperoxic Exposure Persistently Alters Lung Secretoglobins and Annexin A1

1Nationwide Children’s Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA
2The Research Institute at Nationwide Children’s Hospital, 575 Children’s Crossroad, Columbus, OH 43215, USA
3Baylor College of Medicine, Houston, TX 77030, USA

Received 4 April 2013; Revised 27 August 2013; Accepted 28 August 2013

Academic Editor: Hartmut Jaeschke

Copyright © 2013 Thomas M. Raffay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. J. van Marter, “Epidemiology of bronchopulmonary dysplasia,” Seminars in Fetal and Neonatal Medicine, vol. 14, no. 6, pp. 358–366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. L. E. Weisman, “Populations at risk for developing respiratory syncytial virus and risk factors for respiratory syncytial virus severity: infants with predisposing conditions,” Pediatric Infectious Disease Journal, vol. 22, no. 2, supplement, pp. S33–S39, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Greenough, “Long-term pulmonary outcome in the preterm infant,” Neonatology, vol. 93, no. 4, pp. 324–327, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Furman, J. Baley, E. Borawski-Clark, S. Aucott, and M. Hack, “Hospitalization as a measure of morbidity among very low birth weight infants with chronic lung disease,” Journal of Pediatrics, vol. 128, no. 4, pp. 447–452, 1996. View at Publisher · View at Google Scholar · View at Scopus
  5. S. D. Reynolds and A. M. Malkinson, “Clara cell: progenitor for the bronchiolar epithelium,” International Journal of Biochemistry and Cell Biology, vol. 42, no. 1, pp. 1–4, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Lassus, T. J. Nevalainen, J. U. Eskola, and S. Andersson, “Clara-cell secretory protein in preterm infants' tracheal aspirates correlates with maturity and increases in infection,” Pediatric Pulmonology, vol. 30, no. 6, pp. 466–469, 2000.
  7. P. L. Ramsay, F. J. DeMayo, S. E. Hegemier, M. E. Wearden, C. V. Smith, and S. E. Welty, “Clara cell secretory protein oxidation and expression in premature infants who develop bronchopulmonary dysplasia,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 1, pp. 155–161, 2001. View at Scopus
  8. A. J. J. Schrama, A. Bernard, B. J. H. M. Poorthuis, A. H. Zwinderman, H. M. Berger, and F. J. Walther, “Cord blood Clara cell protein CC16 predicts the development of bronchopulmonary dysplasia,” European Journal of Pediatrics, vol. 167, no. 11, pp. 1305–1312, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. C. J. Johnston, G. W. Mango, J. N. Finkelstein, and B. R. Stripp, “Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice,” American Journal of Respiratory Cell and Molecular Biology, vol. 17, no. 2, pp. 147–155, 1997. View at Scopus
  10. S. D. Reynolds, P. R. Reynolds, G. S. Pryhuber, J. D. Finder, and B. R. Stripp, “Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 11, pp. 1498–1509, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. S.-Z. Wang, C. L. Rosenberger, Y.-X. Bao, J. M. Stark, and K. S. Harrod, “Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection,” Journal of Immunology, vol. 171, no. 2, pp. 1051–1060, 2003. View at Scopus
  12. T. M. Watson, S. D. Reynolds, G. W. Mango, I.-M. Boe, J. Lund, and B. R. Stripp, “Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 281, no. 6, pp. L1523–L1530, 2001. View at Scopus
  13. K. S. Harrod, A. D. Mounday, B. R. Stripp, and J. A. Whitsett, “Clara cell secretory protein decreases lung inflammation after acute virus infection,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 275, no. 5, part 1, pp. L924–L930, 1998. View at Scopus
  14. S. D. Reynolds, P. R. Reynolds, J. C. Snyder, F. Whyte, K. J. Paavola, and B. R. Stripp, “CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 293, no. 1, pp. L114–L123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. J. C. Snyder, S. D. Reynolds, J. W. Hollingsworth, Z. Li, N. Kaminski, and B. R. Stripp, “Clara cells attenuate the inflammatory response through regulation of macrophage behavior,” American Journal of Respiratory Cell and Molecular Biology, vol. 42, no. 2, pp. 161–171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. B. B. Warner, L. A. Stuart, R. A. Papes, and J. R. Wispé, “Functional and pathological effects of prolonged hyperoxia in neonatal mice,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 275, no. 1, part 1, pp. L110–L117, 1998. View at Scopus
  17. M. Veiten, K. M. Heyob, L. K. Rogers, and S. E. Welty, “Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure,” Journal of Applied Physiology, vol. 108, no. 5, pp. 1347–1356, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. T. E. Tipple, S. E. Welty, L. D. Nelin, J. M. Hansen, and L. K. Rogers, “Alterations of the thioredoxin system by hyperoxia: implications for alveolar development,” American Journal of Respiratory Cell and Molecular Biology, vol. 41, no. 5, pp. 612–619, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. S. Park, E. Rieger-Fackeldey, B. L. Schanbacher et al., “Altered expressions of fibroblast growth factor receptors and alveolarization in neonatal mice exposed to 85% oxygen,” Pediatric Research, vol. 62, no. 6, pp. 652–657, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. L. K. Rogers, T. E. Tipple, L. D. Nelin, and S. E. Welty, “Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen,” Pediatric Research, vol. 65, no. 1, pp. 33–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Yee, P. R. Chess, S. A. McGrath-Morrow et al., “Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 297, no. 4, pp. L641–L649, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. A. O'Reilly, S. H. Marr, M. Yee, S. A. McGrath-Morrow, and B. P. Lawrence, “Neonatal hyperoxia enhances the inflammatory response in adult mice infected with influenza A virus,” American Journal of Respiratory and Critical Care Medicine, vol. 177, no. 10, pp. 1103–1110, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Niimi, C. L. Keck-Waggoner, N. C. Popescu, Y. Zhou, R. C. Levitt, and S. Kimura, “UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor,” Molecular Endocrinology, vol. 15, no. 11, pp. 2021–2036, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Kurotani, T. Tomita, Q. Yang, B. A. Carlson, C. Chen, and S. Kimura, “Role of secretoglobin 3A2 in lung development,” American Journal of Respiratory and Critical Care Medicine, vol. 178, no. 4, pp. 389–398, 2008. View at Publisher · View at Google Scholar · View at Scopus