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(a) CYP1A2 
408573.fig.001b
(b) CYP2B
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(c) CYP3A
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(d) FMO
Figure 1: Age-related differences in specific activities of biotransformation enzymes with oxidizing activity in rat liver. The white column represents young (6-week-old) rats, and the hatched column indicates old (21-month-old) rats. The activities of individual CYP isoforms were normalized to the total CYP content. Data of each age group represent the mean ± SD (six animals per age group) (*data with , Student’s t-test). CYP = cytochrome P450; FMO = flavine monooxygenase.