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BioMed Research International
Volume 2013 (2013), Article ID 408638, 6 pages
http://dx.doi.org/10.1155/2013/408638
Research Article

Reduced T Cell Receptor Excision Circle Levels in the Colonic Mucosa of Microscopic Colitis Patients Indicate Local Proliferation rather than Homing of Peripheral Lymphocytes to the Inflamed Mucosa

1School of Health and Medical Sciences, Örebro University, 70182 Örebro, Sweden
2Division of Gastroenterology, Department of Medicine, Örebro University Hospital, 70185 Örebro, Sweden
3School of Medicine, Örebro University, 70182 Örebro, Sweden

Received 23 April 2013; Revised 20 June 2013; Accepted 24 June 2013

Academic Editor: Tadayuki Oshima

Copyright © 2013 Ashok Kumar Kumawat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Tysk, J. Bohr, N. Nyhlin, A. Wickbom, and S. Eriksson, “Diagnosis and management of microscopic colitis,” World Journal of Gastroenterology, vol. 14, no. 48, pp. 7280–7288, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. D. S. Pardi and C. P. Kelly, “Microscopic colitis,” Gastroenterology, vol. 140, no. 4, pp. 1155–1165, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Munch, D. Aust, J. Bohr, et al., “Microscopic colitis: current status, present and future challenges: statements of the European Microscopic Colitis Group,” Journal of Crohn's and Colitis, vol. 6, no. 9, pp. 932–945, 2012. View at Publisher · View at Google Scholar
  4. G. Jarnerot, C. Tysk, J. Bohr, and S. Eriksson, “Collagenous colitis and fecal stream diversion,” Gastroenterology, vol. 109, no. 2, pp. 449–455, 1995. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Brand, “Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease,” Gut, vol. 58, no. 8, pp. 1152–1167, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Tsuchiya, T. Hibi, M. Watanabe et al., “Thymectomy in ulcerative colitis: a report of cases over a 13 year period,” Thymus, vol. 17, no. 2, pp. 67–73, 1991. View at Scopus
  7. M. Fritsch Fredin, K. Elgbratt, D. Svensson, L. Jansson, S. Melgar, and E. Hultgren Hörnquist, “Dextran sulfate sodium-induced colitis generates a transient thymic involution—impact on thymocyte subsets,” Scandinavian Journal of Immunology, vol. 65, no. 5, pp. 421–429, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Elgbratt, M. Bjursten, R. Willén, P. W. Bland, and E. H. Hörnquist, “Aberrant T-cell ontogeny and defective thymocyte and colonic T-cell chemotactic migration in colitis-prone Gαi2-deficient mice,” Immunology, vol. 122, no. 2, pp. 199–209, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Somech, “T-cell receptor excision circles in primary immunodeficiencies and other T-cell immune disorders,” Current Opinion in Allergy and Clinical Immunology, vol. 11, no. 6, pp. 517–524, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. D. Hazenberg, M. C. Verschuren, D. Hamann, F. Miedema, and J. J. van Dongen, “T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation,” Journal of Molecular Medicine, vol. 79, no. 11, pp. 631–640, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. T. M. Breit, M. C. M. Verschuren, I. L. M. Wolvers-Tettero, E. J. van Gastel-Mol, K. Hählen, and J. J. M. van Dongen, “Human T cell leukemias with continuous V(D)J recombinase activity for TCR-δ gene deletion,” Journal of Immunology, vol. 159, no. 9, pp. 4341–4349, 1997. View at Scopus
  12. F. Livak and D. G. Schatz, “T-cell receptor α locus V(D)J recombination by-products are abundant in thymocytes and mature T cells,” Molecular and Cellular Biology, vol. 16, no. 2, pp. 609–618, 1996. View at Scopus
  13. A. Fischer, S. Hacein-Bey-Abina, and M. Cavazzana-Calvo, “20 years of gene therapy for SCID,” Nature Immunology, vol. 11, no. 6, pp. 457–460, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Yin, C. A. Rodriguez, W. Hou et al., “Antiretroviral therapy corrects HIV-1-induced expansion of CD8+CD45RA+CD27-CD11abright activated T cells,” Journal of Allergy and Clinical Immunology, vol. 122, no. 1, pp. 166–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. P. P. Tagkalidis, P. R. Gibson, and P. S. Bhathal, “Microscopic colitis demonstrates a T helper cell type 1 mucosal cytokine profile,” Journal of Clinical Pathology, vol. 60, no. 4, pp. 382–387, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. A. K. Kumawat, H. Strid, K. Elgbratt, C. Tysk, J. Bohr, and E. Hultgren Hörnquist, “Microscopic colitis patients have increased proportions of Ki67+ proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells,” Journal of Crohn's and Colitis, 2012. View at Publisher · View at Google Scholar
  17. K. Elgbratt, G. Kurlberg, M. Hahn-Zohric, and E. Hultgren Hörnquist, “Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients,” Clinical and Experimental Immunology, vol. 162, no. 2, pp. 325–336, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. S. R. Targan, B. G. Feagan, R. N. Fedorak et al., “Natalizumab for the treatment of active Crohn's disease: results of the ENCORE trial,” Gastroenterology, vol. 132, no. 5, pp. 1672–1683, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Beaugerie and D. S. Pardi, “Review article: drug-induced microscopic colitis—proposal for a scoring system and review of the literature,” Alimentary Pharmacology and Therapeutics, vol. 22, no. 4, pp. 277–284, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Koetz, E. Bryl, K. Spickschen, W. M. O'Fallon, J. J. Goronzy, and C. M. Weyand, “T cell homeostasis in patients with rheumatoid arthritis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 16, pp. 9203–9208, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Ponchel, A. W. Morgan, S. J. Bingham et al., “Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis,” Blood, vol. 100, no. 13, pp. 4550–4556, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Hug, M. Korporal, I. Schröder et al., “Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis,” Journal of Immunology, vol. 171, no. 1, pp. 432–437, 2003. View at Scopus
  23. C. Göranzon, A. K. Kumawat, E. Hultgren-Hörnqvist et al., “Immunohistochemical characterization of lymphocytes in microscopic colitis,” Journal of Crohn's and Colitis, 2013. View at Publisher · View at Google Scholar
  24. A. Münch, J. D. Söderholm, Å. Öst, and M. Ström, “Increased transmucosal uptake of E. coli K12 in collagenous colitis persists after budesonide treatment,” American Journal of Gastroenterology, vol. 104, no. 3, pp. 679–685, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Bohr, R. Nordfelth, G. Järnerot, and C. Tysk, “Yersinia species in collagenous colitis: a serologic study,” Scandinavian Journal of Gastroenterology, vol. 37, no. 6, pp. 711–714, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. A. K. Kumawat, H. Strid, C. Tysk, J. Bohr, and E. H. Hornquist, “Microscopic colitis patients demonstrate a mixed Th17/Tc17 and Th1/Tc1 mucosal cytokine profile,” Molecular Immunology, vol. 55, no. 3-4, pp. 355–364, 2013. View at Publisher · View at Google Scholar
  27. C. Martinez, A. Gonzalez-Castro, M. Vicario, and J. Santos, “Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome,” Gut Liver, vol. 6, no. 3, pp. 305–315, 2012.
  28. C. Cremon, L. Gargano, A. M. Morselli-Labate et al., “Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms,” American Journal of Gastroenterology, vol. 104, no. 2, pp. 392–400, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. V. S. Chadwick, W. Chen, D. Shu et al., “Activation of the mucosal immune system in irritable bowel syndrome,” Gastroenterology, vol. 122, no. 7, pp. 1778–1783, 2002. View at Scopus