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BioMed Research International
Volume 2013 (2013), Article ID 408680, 7 pages
http://dx.doi.org/10.1155/2013/408680
Clinical Study

Postoperative Adiponectin Levels in Pediatric Patients Undergoing Open Heart Surgery

1Pediatric Intensive Care Department, Chaim Sheba Medical Center, Safra Children’s Hospital, 52621 Tel-Hashomer, Israel
2Sackler School of Medicine, Tel-Aviv University, 39040 Tel-Aviv, Israel
3Institute of Endocrinology, Chaim Sheba Medical Center, Safra Children’s Hospital, 52621 Tel-Hashomer, Israel
4Department of Cardiothoracic Surgery, Chaim Sheba Medical Center, Safra Children’s Hospital, 52621 Tel-Hashomer, Israel
5Pediatric Endocrinology and Diabetes Unit, Chaim Sheba Medical Center, The Edmond and Lily Safra Children’s Hospital, 52621 Tel-Hashomer, Israel

Received 15 April 2013; Revised 5 September 2013; Accepted 6 September 2013

Academic Editor: Rei Shibata

Copyright © 2013 A. Thaler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Adipose tissue is an important endocrine organ that secretes cytokines, including adiponectin, levels of which are negatively correlated with the severity of the inflammatory process. Aim. To assess the time course of adiponectin levels following open heart surgery with cardiopulmonary bypass and its correlation with early postoperative outcomes. Materials and Methods. Blood samples were obtained from 24 children undergoing cardiac surgery and analyzed for adiponectin, C-reactive protein, and other inflammatory markers. Results. Baseline adiponectin levels were negatively correlated with patients’ preoperative weight and age. Postoperative adiponectin levels decreased compared to baseline ( ) and correlated negatively with duration of cardiopulmonary bypass ( , ), length of stay in the pediatric intensive care unit ( , ), and the inotropic score ( , ). Adiponectin levels were positively correlated with sVCAM 1 levels; however, there was no correlation between adiponectin levels and sP selectin, tPA, MCP1, and sCD40. Conclusions. The inflammatory response after open heart surgery with cardiopulmonary bypass is associated with a reduction in adiponectin levels. Prolonged or more complicated surgery induced a more substantial inflammatory process characterized by a significant reduction in adiponectin levels over time and a delayed return to baseline levels.