A Novel Closed-Chest Porcine Model of Chronic Ischemic Heart Failure Suitable for Experimental Research in Cardiovascular Disease
Figure 4
(a) Macroscopic analysis of the porcine heart showing the infarcted area, which appears brighter than the rest of the myocardium. (b) Ventricular wall appears thinned in the area of transmural infarction. (c) Hematoxylin/eosin (H&E) staining of the porcine model showing the haemorrhagic and the necrotic zones in the infarcted area. Infiltration of granulation tissue and fibroblastic/macrophagic cells is also observed (10x magnification). (d) Masson’s Trichrome staining on a selected area of the section confirming both fibrotic connective and granulation tissues (20x magnification).
