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BioMed Research International
Volume 2013 (2013), Article ID 412379, 12 pages
http://dx.doi.org/10.1155/2013/412379
Clinical Study

Effectiveness of Green Tea in a Randomized Human Cohort: Relevance to Diabetes and Its Complications

1ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, Réduit, Mauritius
2School of Pharmacy and Biomedical Sciences, American University of Health Sciences, Signal Hill, CA 90755, USA
3Cardiac Centre, Sir Seewoosagur Ramgoolam National Hospital, Pamplemousses, Mauritius
4Non-Communicable Diseases Unit, Ministry of Health and Quality of Life, Port Louis, Mauritius
5Department of Biochemistry, Apollo Bramwell Hospital, Moka, Mauritius
6Centre for Clinical Research and Education, Apollo Bramwell Hospital, Moka, Mauritius
7Human Resource Development Council, NG Tower, Ebene, Mauritius
8Department of Occupational Therapy, Touro College of Health Sciences, Bay Shore, NY 11706, USA
9Groupe d'Etude sur l'Inflammation Chronique et l'Obésité, Université de La Réunion, Plate-forme CYROI, Saint Denis, 97400 La Réunion, France

Received 12 April 2013; Revised 17 July 2013; Accepted 7 August 2013

Academic Editor: Yvonne F. Heerkens

Copyright © 2013 Naushad Ali Toolsee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Epidemiological studies have argued that green tea could mitigate diabetes and its complications. This study investigated the phytophenolic profile of Mauritian green tea and its antioxidant propensity. The effect of green tea on the risk factors: waist-hip ratio, glucose level, arterial pressure, antioxidant status, and alanine aminotransferase (ALT) in prediabetics was assessed. The experimental group consumed 3 cups of green tea daily for 14 weeks followed by a 2-week washout period. The control group followed a water regimen. Green tea contained high level of phenolics related to its antioxidant power. Green tea suppressed waist-hip ratio of women from a significant increase and suppressed mean arterial pressure of men and women from a significant decrease after week 14. It reduced ALT level in women by 13.0% ( ) while increasing the antioxidant potential of men and women sera by 2.7% ( ) and 5.1% ( ). The study timescale may have been too short to enable demonstration of effects on fasting plasma glucose and HbA1c outcomes. Green tea regimen could form part of a healthy lifestyle that might ameliorate features of metabolic syndrome and subsequent risks for diabetes and its complications. This trial is registered with ClinicalTrials.gov NCT01248143.