Polyisoprenylated Methylated Protein Methyl Esterase Is Both Sensitive to Curcumin and Overexpressed in Colorectal Cancer: Implications for Chemoprevention and Treatment

Table 3

Association of PMPMEase immunoreactivity with the pathologic features of colon cancer. Significantly higher PMPMEase immunoreactivities were observed in the different types, grades, and stages of colon cancers as shown by the means ± SEM versus normal tissues compared by ANOVA followed by Dunnet’s post test.

Characteristics	PMPMEase Staining Intensity, N (%)					Missing	Mean Scores	𝑃-value
	1–100; Trace	101–200; Weak	201–300; Intermediate	301–400; Strong	401–500; Very strong
Normal	11 (75.0)	3 (25.0)	0	0	0	0	91.7±11.4
NAT	4 (100)	0	0	0	0	0	75.0±14.4
Histology
Adenocarcinomas	7 (4.0)	30 (17.1)	57 (32.6)	54 (30.9)	20 (11.4)	7 (4.0)	294.8±7.8	0.0001
Mucinous adenocarcinoma	1 (6.7)	1 (6.7)	6 (40.0)	6 (40.0)	1 (6.7)	0	310.0±22.6
Papillary adenoma	0	0	0	1 (100.0)	0	0
Signet ring cell carcinoma	0	0	0	1 (100.0)	0	0
Pathological stage
I	2 (2.2)	13 (14.1)	33 (35.9)	32 (34.8)	10 (10.9)	2 (2.2)	306.1±10.0	0.0001
II	5 (5.6)	16 (18.0)	26 (29.2)	28 (31.5)	11 (12.4)	3 (3.4)	291.6±11.2
III	1 (16.7)	1 (16.7)	1 (16.7)	2 (33.3)	0	1 (16.7)	270.0±53.3
IV	0	1 (20.0)	3 (60.0)	0	0	1 (20.0)	218.8±35.9
Grade
1	2 (5.7)	5 (14.3)	8 (22.9)	18 (51.4)	2 (5.7)	0	306.4±17.1	0.0001
2	4 (4.0)	22 (21.8)	37 (36.7)	25 (24.8)	10 (9.9)	3 (3.0)	281.6±9.9
2-3	0	0	5 (50.0)	5 (50.0)	0	0	302.5±18.1
3	2 (9.1)	3 (13.6)	10 (45.5)	5 (22.7)	2 (9.1)	0	270.5±21.7
Not determined	0	1 (4.2)	3 (12.5)	9 (37.5)	7 (29.2)	4 (16.7)	377.5±18.6