Polyisoprenylated Methylated Protein Methyl Esterase Is Both Sensitive to Curcumin and Overexpressed in Colorectal Cancer: Implications for Chemoprevention and Treatment

Table 4

PMPMEase (CES1) gene is overexpressed in human colorectal cancers. Oncomine studies used in this analysis are shown below.

Cases	Number of cases with fold change greater than 2		Year of study	References
	Downregulated	Upregulated
70	7 (10%)	28 (40%)	2010	[39]
22	5 (22%)	12 (55%)	2007	[40]
48	1 (2%)	16 (33%)	2006	[41]
100		33 (33%)	2007	[42]
12		7 (58%)	2001	[43]
13		9 (69%)	2003	[44]
154	10 (7%)	50 (32%)	2009	[45]
23		3 (13%)	2008	[46]
80	12 (15%)	58 (73%)	2007	[47]
55	2 (4%)	9 (16%)	2007	[48]
177		59 (33%)	2010	[49]
62		7 (11%)	2009	[50]
42	4 (10%)	14 (33%)	2006	[51]
104		18 (17%)	2011	[52]
176		82 (46%)	2011	[53]

Number of cases with significant fold change (𝑃<0.001) and the percentage (in brackets) of the number of their respective cases are indicated.